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SB-431542 Identifiers ChEMBL CHEMBL440084 Jmol-3D images Image 1 SMILES NC(=O)c1ccc(cc1)c2nc(c3ccc4OCOc4c3)c([nH]2)c5ccccn5 Properties Molecular formula C22H16N4O3 Molar mass 384.4 Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references SB-431542 is a drug candidate developed by GlaxoSmithKline (GSK) as an inhibitor of the activin receptor-like kinase (ALK) receptors, ALK5, ALK4 and ALK7. It also suppressed the TGF-beta-induced proliferation of osteosarcoma cells in humans. [1] References ^ Laping, NJ; Grygielko E, Mathur A, Butter S, Bomberger J, Tweed C, Martin W, Fornwald J, Lehr R, Harling J, Gaster L, Callahan JF, Olson BA (2002). "Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542". Molecular Pharmacology 62 (1): 58-64. PMID 12065755.