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Glycosyltransferase family 10 (fucosyltransferase) Identifiers Symbol Glyco_transf_10 Pfam PF00852 InterPro IPR001503 Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum 2nzw, 2nzx, 2nzy A fucosyltransferase is an enzyme that transfers an L-fucose sugar from a GDP-fucose (guanosine diphosphate-fucose) donor substrate to an acceptor substrate. The acceptor substrate can be another sugar such as the transfer of a fucose to a core GlcNAc (N-acetylglucosamine) sugar as in the case of N-linked glycosylation, or to a protein, as in the case of O-linked glycosylation produced by O-fucosyltransferase. There are various fucosyltransferases in mammals, the vast majority of which, are located in the Golgi apparatus. The O-fucosyltransferases have recently been shown to localize to the endoplasmic reticulum (ER). Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates attached to lipids or proteins [Reid M.E., Lomas-Francis C. The Blood Group Antigen FactsBook Academic Press, London / San Diego, (1997)]. Galactoside 3(4)-L-fucosyltransferase (EC 2.4.1.65) belongs to the Lewis blood group system and is associated with Le(a/b) antigen. Contents 1 Classification 2 Human proteins containing this domain 3 References 4 See also 5 External links Classification Glycosyltransferase family 10 CAZY GT_10 comprises enzymes with two known activities; galactoside 3(4)-L-fucosyltransferase (EC 2.4.1.65) and galactoside 3-fucosyltransferase (EC 2.4.1.152). The galactoside 3-fucosyltransferases display similarities with the alpha-2 and alpha-6-fucosyltranferases[1]. The biosynthesis of the carbohydrate antigen sialyl Lewis X (sLe(x)) is dependent on the activity of an galactoside 3-fucosyltransferase. This enzyme catalyses the transfer of fucose from GDP-beta-fucose to the 3-OH of N-acetylglucosamine present in lactosamine acceptors[2]. Human proteins containing this domain FT1A; FUT10; FUT11; FUT3; FUT4; FUT5; FUT6; FUT7; FUT9; References ^ Breton C, Oriol R, Imberty A (1998). "Conserved structural features in eukaryotic and prokaryotic fucosyltransferases". Glycobiology 8 (1): 87–94. PMID 9451017.  ^ Britten CJ, Bird MI (1997). "Chemical modification of an alpha 3-fucosyltransferase; definition of amino acid residues essential for enzyme activity". Biochim. Biophys. Acta 1334 (1): 57–64. PMID 9042366.  See also fucosylation External links MeSH Fucosyltransferases This transferase article is a stub. You can help Wikipedia by expanding it.v · d · e v · d · eTransferases: glycosyltransferases (EC 2.4) 2.4.1: Hexosyl- transferases Glucosyl- Phosphorylase (Starch, Glycogen, Myo-) · Glycogen synthase · Debranching enzyme · Branching enzyme · 1,3-beta-glucan synthase · Ceramide glucosyltransferase Galactosyl- Lactose synthase · B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase · Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (C1GALT1) Glucuronosyl- B3GAT1, B3GAT2, B3GAT3 UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10 UGT2A1, UGT2A2, UGT2A3, UGT2B4, UGT2B7, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28 Hyaluronan synthase: HAS1 · HAS2 · HAS3 Fucosyl- POFUT1 · POFUT2 · FUT1 · FUT2 · FUT3 · FUT4 · FUT5 · FUT6 · FUT7 · FUT8 · FUT9 · FUT10 · FUT11 Mannosyl- Dolichyl-phosphate-mannose-protein mannosyltransferase (POMT1, POMT2) · DPM1 · DPM3 ALG1 · ALG2 · ALG3 · ALG6 · ALG8 · ALG9 · ALG12 2.4.2: Pentosyl- transferases Ribose ADP-ribosyltransferase NAD+:diphthamide ADP-ribosyltransferase (Diphtheria toxin) NAD(P)+:arginine ADP-ribosyltransferase (Pertussis toxin · Cholera toxin) Poly ADP ribose polymerase Sirtuin Phosphoribosyltransferase Adenine phosphoribosyltransferase · Hypoxanthine-guanine phosphoribosyltransferase · Uracil phosphoribosyltransferase · Amidophosphoribosyltransferase Other Purine nucleoside phosphorylase Other Xylosyltransferase · Arabinosyltransferase (Indolylacetylinositol arabinosyltransferase) 2.4.99: Sialyl transferases Beta-galactoside alpha-2,6-sialyltransferase · Monosialoganglioside sialyltransferase · ST8SIA4 B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6