Your IP: 18.207.102.38 United States Near: Cambridge, Massachusetts, United States

Lookup IP Information

Previous 1 2 3 4 5 6 7 8 Next

Below is the list of all allocated IP address in 254.144.0.0 - 254.144.255.255 network range, sorted by latency.

URB602 IUPAC name Cyclohexyl [1,1'-biphenyl]-3-ylcarbamate Other names [1,​1'-​Biphenyl]-​3-​yl-​carbamic acid,​ cyclohexyl ester Identifiers CAS number 565460-15-3 Y PubChem 10979337 ChemSpider 9154538 Y Jmol-3D images Image 1 SMILES O=C(OC1CCCCC1)​Nc1cccc(c1)​c1ccccc1 InChI InChI=1S/C19H21NO2/c21-19(22-18-12-5-2-6-13-18)20-17-11-7-10-16(14-17)15-8-3-1-4-9-15/h1,3-4,7-11,14,18H,2,5-6,12-13H2,(H,20,21) Y Key: HHVUFQYJOSFTEH-UHFFFAOYSA-N Y Properties Molecular formula C19H21NO2 Molar mass 295.38 g mol−1 Appearance Crystalline solid  Y(what is this?)  (verify) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox references URB602 ([1,1'-biphenyl]-3-yl-carbamic acid, cyclohexyl ester) is a compound that has been found to inhibit hydrolysis of monoacyl glycerol compounds, such as 2-arachidonoylglycerol (2-AG) and 2-oleoylglycerol (2-OG). It was first described in 2003.[1] A study performed in 2005 found that the compound had specificity for metabolizing 2-AG over anandamide (another cannabinoid ligand) in rat brain presumably by inhibiting the enzyme monoacylglycerol lipase (MAGL), which is the primary metabolic enzyme of 2-AG.[2] However, subsequent studies have shown that URB602 lacks specificity for MAGL inhibition in vitro.[3] References ^ Tarzia, G; Duranti, A; Tontini, A; Piersanti, G; Mor, M; Rivara, S; Plazzi, PV; Park, C et al. (2003). "Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors". Journal of medicinal chemistry 46 (12): 2352–60. doi:10.1021/jm021119g. PMID 12773040.  ^ Hohmann, Andrea G.; Suplita, Richard L.; Bolton, Nathan M.; Neely, Mark H.; Fegley, Darren; Mangieri, Regina; Krey, Jocelyn F.; Michael Walker, J. et al. (2005). "An endocannabinoid mechanism for stress-induced analgesia". Nature 435 (7045): 1108–12. Bibcode 2005Natur.435.1108H. doi:10.1038/nature03658. PMID 15973410.  ^ Vandevoorde, S; Jonsson, K-O; Labar, G; Persson, E; Lambert, D M; Fowler, C J (2007). "Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysisin vitro". British Journal of Pharmacology 150 (2): 186–91. doi:10.1038/sj.bjp.0706971. PMC 2042901. PMID 17143303.