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edit hook homolog 2 (Drosophila) Identifiers Symbols HOOK2; HK2; FLJ26218 External IDs OMIM: 607824 MGI: 2181664 HomoloGene: 8332 GeneCards: HOOK2 Gene Gene Ontology Molecular function • protein binding • identical protein binding • microtubule binding Cellular component • cytoskeleton • HOPS complex • FHF complex • microtubule • centrosome • cytoplasm Biological process • early endosome to late endosome transport • microtubule cytoskeleton organization • endosome to lysosome transport • endocytosis • endosome organization • protein transport • lysosome organization Sources: Amigo / QuickGO Orthologs Species Human Mouse Entrez 29911 170833 Ensembl ENSG00000095066 ENSMUSG00000052566 UniProt Q96ED9 Q7TMK6 RefSeq (mRNA) NM_013312 NM_133255 RefSeq (protein) NP_001093646 NP_573518 Location (UCSC) Chr 19: 12.73 - 12.75 Mb Chr 8: 87.51 - 87.53 Mb PubMed search [1] [2] Protein Hook homolog 2 (HK2) is a protein[1] that in humans is encoded by the HOOK2 gene.[2][3] Function Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[3] References ^ Krämer H, Phistry M (February 1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics 151 (2): 675–84. PMC 1460498. PMID 9927460.  ^ Walenta JH, Didier AJ, Liu X, Krämer H (March 2001). "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins". J. Cell Biol. 152 (5): 923–34. doi:10.1083/jcb.152.5.923. PMC 2198811. PMID 11238449.  ^ a b "Entrez Gene: hook homolog 2 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29911.  Further reading Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.  Xu L, Sowa ME, Chen J, et al. (2008). "An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.". Mol. Biol. Cell 19 (12): 5059-71. doi:10.1091/mbc.E08-05-0473. PMID 18799622.  Moynihan KL, Pooley R, Miller PM, et al. (2009). "Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome.". Mol. Biol. Cell 20 (22): 4790-803. doi:10.1091/mbc.E09-07-0560. PMID 19793914.  Szebenyi G, Wigley WC, Hall B, et al. (2007). "Hook2 contributes to aggresome formation.". BMC Cell Biol. 8: 19. doi:10.1186/1471-2121-8-19. PMID 17540036.  Szebenyi G, Hall B, Yu R, et al. (2007). "Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function.". Traffic 8 (1): 32-46. doi:10.1111/j.1600-0854.2006.00511.x. PMID 17140400.  Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1.". Traffic 6 (6): 442-58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442.  This article on a gene on chromosome 19 is a stub. You can help Wikipedia by expanding it.v · d · e