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edit Histone cluster 1, H4i PDB rendering based on 1aoi. Available structures PDB 1aoi, 1eqz, 1f66, 1hio, 1hq3, 1id3, 1kx3, 1kx4, 1kx5, 1m18, 1m19, 1m1a, 1p34, 1p3a, 1p3b, 1p3f, 1p3g, 1p3i, 1p3k, 1p3l, 1p3m, 1p3o, 1p3p, 1s32, 1tzy, 1u35, 1zbb, 1zla, 2aro, 2cv5, 2f8n, 2fj7, 2hio, 2hue, 2io5, 2nzd Identifiers Symbols HIST1H4I; H4/m; H4FM; H4M External IDs OMIM: 602833 MGI: 2448425 HomoloGene: 88583 GeneCards: HIST1H4I Gene Gene Ontology Orthologs Species Human Mouse Entrez 8294 319157 Ensembl n/a n/a UniProt n/a n/a RefSeq (mRNA) NM_003495 NM_175655 RefSeq (protein) NP_003486 NP_783586 Location (UCSC) n/a n/a PubMed search [1] [2] Histone H4 is a protein that in humans is encoded by the HIST1H4I gene.[1][2][3][4] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.[4] References ^ Akasaka T, Miura I, Takahashi N, Akasaka H, Yonetani N, Ohno H, Fukuhara S, Okuma M (Jan 1997). "A recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma results in replacement of the 5' regulatory region of BCL6 with a novel H4 histone gene". Cancer Res 57 (1): 7–12. PMID 8988030.  ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656.  ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.  ^ a b "Entrez Gene: HIST1H4I histone cluster 1, H4i". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8294.  Further reading Albig W, Kardalinou E, Drabent B, et al. (1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes.". Genomics 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825.  Turner BM, O'Neill LP, Allan IM (1989). "Histone H4 acetylation in human cells. Frequency of acetylation at different sites defined by immunolabeling with site-specific antibodies.". FEBS Lett. 253 (1-2): 141–5. doi:10.1016/0014-5793(89)80947-0. PMID 2474456.  Pauli U, Chrysogelos S, Stein G, et al. (1987). "Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene.". Science 236 (4806): 1308–11. doi:10.1126/science.3035717. PMID 3035717.  Ebralidse KK, Grachev SA, Mirzabekov AD (1988). "A highly basic histone H4 domain bound to the sharply bent region of nucleosomal DNA.". Nature 331 (6154): 365–7. doi:10.1038/331365a0. PMID 3340182.  Sierra F, Stein G, Stein J (1983). "Structure and in vitro transcription of a human H4 histone gene.". Nucleic Acids Res. 11 (20): 7069–86. doi:10.1093/nar/11.20.7069. PMC 326439. PMID 6314274.  Drabent B, Kardalinou E, Bode C, Doenecke D (1995). "Association of histone H4 genes with the mammalian testis-specific H1t histone gene.". DNA Cell Biol. 14 (7): 591–7. doi:10.1089/dna.1995.14.591. PMID 7626218.  Albig W, Meergans T, Doenecke D (1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes.". Gene 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620.  Albig W, Kioschis P, Poustka A, et al. (1997). "Human histone gene organization: nonregular arrangement within a large cluster.". Genomics 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.  El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter.". Mol. Cell. Biol. 18 (5): 2535–44. PMC 110633. PMID 9566873.  Albig W, Trappe R, Kardalinou E, et al. (1999). "The human H2A and H2B histone gene complement.". Biol. Chem. 380 (1): 7–18. doi:10.1515/BC.1999.002. PMID 10064132.  Ahn J, Gruen JR (1999). "The genomic organization of the histone clusters on human 6p21.3.". Mamm. Genome 10 (7): 768–70. doi:10.1007/s003359901089. PMID 10384058.  Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.". Virology 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.  Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA.". Virology 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter.". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.  Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.  v · d · ePDB gallery 1aoi: COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT   1eqz: X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION   1f66: 2.6 A CRYSTAL STRUCTURE OF A NUCLEOSOME CORE PARTICLE CONTAINING THE VARIANT HISTONE H2A.Z   1hq3: CRYSTAL STRUCTURE OF THE HISTONE-CORE-OCTAMER IN KCL/PHOSPHATE   1id3: CRYSTAL STRUCTURE OF THE YEAST NUCLEOSOME CORE PARTICLE REVEALS FUNDAMENTAL DIFFERENCES IN INTER-NUCLEOSOME INTERACTIONS   1kx3: X-Ray Structure of the Nucleosome Core Particle, NCP146, at 2.0 A Resolution   1kx4: X-Ray Structure of the Nucleosome Core Particle, NCP146b, at 2.6 A Resolution   1kx5: X-Ray Structure of the Nucleosome Core Particle, NCP147, at 1.9 A Resolution   1m18: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA   1m19: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA   1m1a: LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA   1p34: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants   1p3a: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants   1p3b: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants   1p3f: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants   1p3g: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants   1p3i: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants   1p3k: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants   1p3l: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants   1p3m: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants   1p3o: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants   1p3p: Crystallographic Studies of Nucleosome Core Particles containing Histone 'Sin' Mutants   1s32: Molecular Recognition of the Nucleosomal 'Supergroove'   1tzy: Crystal Structure of the Core-Histone Octamer to 1.90 Angstrom Resolution   1u35: Crystal structure of the nucleosome core particle containing the histone domain of macroH2A   1zbb: Structure of the 4_601_167 Tetranucleosome   1zla: X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core   2aro: Crystal Structure Of The Native Histone Octamer To 2.1 Angstrom Resolution, Crystalised In The Presence Of S-Nitrosoglutathione   2cv5: Crystal structure of human nucleosome core particle   2f8n: 2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes   2fj7: Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element   2hio: HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN   2hue: Structure of the H3-H4 chaperone Asf1 bound to histones H3 and H4   2io5: Crystal structure of the CIA- histone H3-H4 complex   2nzd: Nucleosome core particle containing 145 bp of DNA   This protein-related article is a stub. 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