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edit Neurotensin receptor 2 Identifiers Symbols NTSR2; NTR2 External IDs OMIM: 605538 MGI: 108018 HomoloGene: 7452 IUPHAR: NTS2 GeneCards: NTSR2 Gene Gene Ontology Molecular function • rhodopsin-like receptor activity • receptor activity • neurotensin receptor activity, G-protein coupled Cellular component • integral to plasma membrane • membrane Biological process • G-protein coupled receptor protein signaling pathway • sensory perception Sources: Amigo / QuickGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 23620 18217 Ensembl ENSG00000169006 ENSMUSG00000020591 UniProt O95665 Q8VIF4 RefSeq (mRNA) XM_001129997 NM_008747 RefSeq (protein) XP_001129997 NP_032773 Location (UCSC) Chr 2: 11.72 - 11.73 Mb Chr 12: 16.68 - 16.69 Mb PubMed search [1] [2] Neurotensin receptor type 2 is a protein that in humans is encoded by the NTSR2 gene.[1][2][3] The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.[3] Contents 1 See also 2 References 3 External links 4 Further reading See also Neurotensin receptor References ^ Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P, Caput D (Jul 1996). "Molecular cloning of a levocabastine-sensitive neurotensin binding site". FEBS Lett 386 (2-3): 91–4. doi:10.1016/0014-5793(96)00397-3. PMID 8647296.  ^ Vita N, Oury-Donat F, Chalon P, Guillemot M, Kaghad M, Bachy A, Thurneyssen O, Garcia S, Poinot-Chazel C, Casellas P, Keane P, Le Fur G, Maffrand JP, Soubrie P, Caput D, Ferrara P (Feb 1999). "Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells". Eur J Pharmacol 360 (2-3): 265–72. doi:10.1016/S0014-2999(98)00678-5. PMID 9851594.  ^ a b "Entrez Gene: NTSR2 neurotensin receptor 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23620.  External links "Neurotensin Receptors: NTS2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3005.  Further reading Vincent JP, Mazella J, Kitabgi P (1999). "Neurotensin and neurotensin receptors.". Trends Pharmacol. Sci. 20 (7): 302–9. doi:10.1016/S0165-6147(99)01357-7. PMID 10390649.  Mazella J, Botto JM, Guillemare E, et al. (1996). "Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain.". J. Neurosci. 16 (18): 5613–20. PMID 8795617.  Ramez M, Bagot M, Nikolova M, et al. (2001). "Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes.". J. Invest. Dermatol. 117 (3): 687–93. doi:10.1046/j.0022-202x.2001.01439.x. PMID 11564178.  Martin S, Vincent JP, Mazella J (2002). "Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue.". J. Cell. Sci. 115 (Pt 1): 165–73. PMID 11801734.  Bourcier T, Rondeau N, Paquet S, et al. (2002). "Expression of neurotensin receptors in human corneal keratocytes.". Invest. Ophthalmol. Vis. Sci. 43 (6): 1765–71. PMID 12036977.  Leyton J, Garcia-Marin L, Jensen RT, Moody TW (2002). "Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells.". Eur. J. Pharmacol. 442 (3): 179–86. doi:10.1016/S0014-2999(02)01539-X. PMID 12065070.  Somaï S, Gompel A, Rostène W, Forgez P (2002). "Neurotensin counteracts apoptosis in breast cancer cells.". Biochem. Biophys. Res. Commun. 295 (2): 482–8. doi:10.1016/S0006-291X(02)00703-9. PMID 12150975.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  Holst B, Holliday ND, Bach A, et al. (2005). "Common structural basis for constitutive activity of the ghrelin receptor family.". J. Biol. Chem. 279 (51): 53806–17. doi:10.1074/jbc.M407676200. PMID 15383539.  Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.  This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.v · d · e This article incorporates text from the United States National Library of Medicine, which is in the public domain. v · d · eCell surface receptor: G protein-coupled receptors Class A: Rhodopsin like Neurotransmitter Adrenergic α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3 Purinergic Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14) Serotonin (all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7) Other Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9) Metabolites and signaling molecules Eicosanoid CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane Other Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate Peptide Neuropeptide B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2) Other Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Chemokine · Cholecystokinin (A, B) · Endothelin (A, B) · Formyl peptide (1, 2, 3) · FSH · Galanin (1, 2, 3) · GHB receptor · Gonadotropin-releasing hormone (1, 2) · Ghrelin · Kisspeptin · Luteinizing hormone/choriogonadotropin · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Orexin (1, 2) · Oxytocin · Prokineticin (1, 2) · Prolactin-releasing peptide · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2) Miscellaneous Orphan GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183) Other Adrenomedullin · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Protease-activated (1, 2, 3, 4) · SREB (1, 2, 3) Class B: Secretin like Orphan GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157) Other Brain-specific angiogenesis inhibitor (1, 2, 3) · Cadherin (1, 2, 3) · Calcitonin · CALCRL · CD97 · Corticotropin-releasing hormone (1, 2) · EMR (1, 2, 3) · Glucagon (GR, GIPR, GLP1R, GLP2R) · Growth hormone releasing hormone · PACAPR1 · GPR · Latrophilin (1, 2, 3, ELTD1) · Methuselah-like proteins · Parathyroid hormone (1, 2) · Secretin · Vasoactive intestinal peptide (1, 2) Class C: Metabotropic glutamate / pheromone Taste TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50) Other Calcium-sensing receptor · GABA B (1, 2) · Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR (156, 158, 179) · RAIG (1, 2, 3, 4) Class F: Frizzled / Smoothened Frizzled Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) Smoothened Smoothened B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp) v · d · eNeuropeptidergics Cholecystokinin CCKA Agonists: Cholecystokinin • CCK-4 Antagonists: Asperlicin • Proglumide • Lorglumide • Devazepide • Dexloxiglumide CCKB Agonists: Cholecystokinin • CCK-4 • Gastrin Antagonists: Proglumide • CI-988 CRH CRF1 Agonists: Corticotropin releasing hormone Antagonists: Antalarmin • CP-154,526 • Pexacerfont CRF2 Agonists: Corticotropin releasing hormone Galanin GAL1 Agonists: Galanin • Galanin-like peptide • Galmic • Galnon GAL2 Agonists: Galanin • Galanin-like peptide • Galmic • Galnon GAL3 Agonists: Galanin • Galmic • Galnon Ghrelin Agonists: Ghrelin • Capromorelin • MK-677 • Sermorelin • SM-130,686 • Tabimorelin MCH MCH1 Agonists: Melanin concentrating hormone Antagonists: ATC-0175 • GW-803,430 • NGD-4715 • SNAP-7941 • SNAP-94847 MCH2 Agonists: Melanin concentrating hormone Melanocortin MC1 Agonists: alpha-MSH • Afamelanotide • Bremelanotide • Melanotan II Antagonists: Agouti signalling peptide MC2 Agonists: ACTH • Cosyntropin • Tetracosactide MC3 Agonists: alpha-MSH • Bremelanotide • Melanotan II MC4 Agonists: alpha-MSH • Bremelanotide • Melanotan II • THIQ Antagonists: Agouti-related peptide MC5 Agonists: alpha-MSH • Melanotan II Neuropeptide S Agonists: Neuropeptide S Antagonists: SHA-68 Neuropeptide Y Y1 Agonists: Neuropeptide Y • Peptide YY Antagonists: BIBP-3226 Y2 Agonists: Neuropeptide Y • Peptide YY Antagonists: BIIE-0246 Y4 Agonists: Neuropeptide Y • Pancreatic polypeptide • Peptide YY Antagonists: UR-AK49 Y5 Agonists: Neuropeptide Y • Peptide YY Antagonists: Lu AA-33810 Neurotensin NTS1 Agonists: Neurotensin • Neuromedin N Antagonists: SR-48692 • SR-142,948 NTS2 Agonists: Neurotensin Antagonists: Levocabastine • SR-142,948 Opioid see Template:Opioids Orexin OX1 Agonists: Orexin-A Antagonists: Almorexant • SB-334,867 • SB-408,124 • SB-649,868 OX2 Agonists: Orexin-A Antagonists: Almorexant • SB-649,868 • TCS-OX2-29 Oxytocin Agonists: Carbetocin • Demoxytocin • Oxytocin • WAY-267,464 Antagonists: Atosiban • L-371,257 • L-368,899 Tachykinin NK1 Agonists: Substance P Antagonists: Aprepitant • Befetupitant • Casopitant • CI-1021 • CP-96,345 • CP-99,994 • CP-122,721 • Dapitant • Ezlopitant • FK-888 • Fosaprepitant • GR-203,040 • GW-597,599 • HSP-117 • L-733,060 • L-741,671 • L-743,310 • L-758,298 • Lanepitant • LY-306,740 • Maropitant • Netupitant • NKP-608 • Nolpitantium • Orvepitant • RP-67,580 • SDZ NKT 343 • Vestipitant • Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159,897 • Ibodutant • Saredutant NK3 Agonists: Neurokinin B Antagonists: Osanetant • Talnetant Vasopressin V1A Agonists: Desmopressin • Felypressin • Ornipressin • Terlipressin • Vasopressin Antagonists: Conivaptan • Demeclocycline • Relcovaptan V1B Agonists: Felypressin • Ornipressin • Terlipressin • Vasopressin Antagonists: Demeclocycline • Nelivaptan V2 Agonists: Desmopressin • Ornipressin • Vasopressin Antagonists: Conivaptan • Demeclocycline • Lixivaptan • Mozavaptan • Satavaptan • Tolvaptan