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This article is an orphan, as few or no other articles link to it. Please introduce links to this page from related articles; suggestions may be available. (February 2009) edit Cysteine-rich protein 2 PDB rendering based on 2cu8. Available structures PDB 2cu8 Identifiers Symbols CRIP2; ESP1; CRP2; CRIP External IDs OMIM: 601183 MGI: 1915587 HomoloGene: 36065 GeneCards: CRIP2 Gene Gene Ontology Molecular function • zinc ion binding • metal ion binding Sources: Amigo / QuickGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1397 68337 Ensembl ENSG00000182809 ENSMUSG00000006356 UniProt P52943 Q4FJU3 RefSeq (mRNA) NM_001312 NM_024223 RefSeq (protein) NP_001303 NP_077185 Location (UCSC) Chr 14: 105.01 - 105.02 Mb Chr 12: 113.59 - 113.59 Mb PubMed search [1] [2] Cysteine-rich protein 2 is a protein that in humans is encoded by the CRIP2 gene.[1][2][3][4] CRIP2 and the closely related CRIP1 are cysteine-rich proteins containing two LIM domains. They are highly expressed during cardiovascular development and act to bridge serum response factor and GATA proteins and stimulate smooth muscle target genes.[5] References ^ Tsui SK, Chan PP, Cheuk CW, Liew CC, Waye MM, Fung KP, Lee CY (Feb 1997). "A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation". Biochem Mol Biol Int 39 (4): 747–54. PMID 8843343.  ^ Karim MA, Ohta K, Egashira M, Jinno Y, Niikawa N, Matsuda I, Indo Y (January 1996). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3". Genomics 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID 8824798.  ^ Huber A, Neuhuber WL, Klugbauer N, Ruth P, Allescher HD (Mar 2000). "Cysteine-rich protein 2, a novel substrate for cGMP kinase I in enteric neurons and intestinal smooth muscle". J Biol Chem 275 (8): 5504–11. doi:10.1074/jbc.275.8.5504. PMID 10681529.  ^ "Entrez Gene: CRIP2 cysteine-rich protein 2".  ^ Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ (January 2003). "Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors". Dev. Cell 4 (1): 107–18. doi:10.1016/S1534-5807(02)00396-9. PMID 12530967.  Further reading Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  van Ham M, Croes H, Schepens J, et al. (2004). "Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL.". Genes Cells 8 (7): 631–44. doi:10.1046/j.1365-2443.2003.00660.x. PMID 12839623.  Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.  v · d · ePDB gallery 2cu8: Solution structure of the LIM domain of human Cysteine-rich protein 2   This article on a gene on chromosome 14 is a stub. You can help Wikipedia by expanding it.v · d · e