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edit Telomeric repeat binding factor 2, interacting protein PDB rendering based on 1fex. Available structures PDB 1fex Identifiers Symbols TERF2IP; RAP1; DRIP5 External IDs OMIM: 605061 MGI: 1929871 HomoloGene: 10357 GeneCards: TERF2IP Gene Gene Ontology Molecular function • DNA binding • protein binding • single-stranded telomeric DNA binding Cellular component • nuclear chromosome • chromosome, telomeric region • nucleus Biological process • telomere maintenance via telomerase • regulation of transcription Sources: Amigo / QuickGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 54386 57321 Ensembl ENSG00000166848 ENSMUSG00000033430 UniProt Q9NYB0 Q8C2Y1 RefSeq (mRNA) NM_018975 NM_020584 RefSeq (protein) NP_061848 NP_065609 Location (UCSC) Chr 16: 74.24 - 74.25 Mb Chr 8: 114.9 - 114.91 Mb PubMed search [1] [2] Telomeric repeat-binding factor 2-interacting protein 1 is a protein that in humans is encoded by the TERF2IP gene.[1][2] Interactions TERF2IP has been shown to interact with Ku80,[3] Rad50[3] and TERF2.[3][1][4] References ^ a b Li B, Oestreich S, de Lange T (Jul 2000). "Identification of human Rap1: implications for telomere evolution". Cell 101 (5): 471–83. doi:10.1016/S0092-8674(00)80858-2. PMID 10850490.  ^ "Entrez Gene: TERF2IP telomeric repeat binding factor 2, interacting protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54386.  ^ a b c O'Connor, Matthew S; Safari Amin, Liu Dan, Qin Jun, Songyang Zhou (Jul. 2004). "The human Rap1 protein complex and modulation of telomere length". J. Biol. Chem. (United States) 279 (27): 28585–91. doi:10.1074/jbc.M312913200. ISSN 0021-9258. PMID 15100233.  ^ Zhu, X D; Küster B, Mann M, Petrini J H, de Lange T (Jul. 2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres". Nat. Genet. (UNITED STATES) 25 (3): 347–52. doi:10.1038/77139. ISSN 1061-4036. PMID 10888888.  Further reading Zhu XD, Küster B, Mann M, et al. (2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.". Nat. Genet. 25 (3): 347–52. doi:10.1038/77139. PMID 10888888.  Hanaoka S, Nagadoi A, Yoshimura S, et al. (2001). "NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains.". J. Mol. Biol. 312 (1): 167–75. doi:10.1006/jmbi.2001.4924. PMID 11545594.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  Loayza D, De Lange T (2003). "POT1 as a terminal transducer of TRF1 telomere length control.". Nature 423 (6943): 1013–8. doi:10.1038/nature01688. PMID 12768206.  Li B, de Lange T (2004). "Rap1 affects the length and heterogeneity of human telomeres.". Mol. Biol. Cell 14 (12): 5060–8. doi:10.1091/mbc.E03-06-0403. PMC 284807. PMID 14565979.  Zhu XD, Niedernhofer L, Kuster B, et al. (2004). "ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.". Mol. Cell 12 (6): 1489–98. doi:10.1016/S1097-2765(03)00478-7. PMID 14690602.  Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  O'Connor MS, Safari A, Liu D, et al. (2004). "The human Rap1 protein complex and modulation of telomere length.". J. Biol. Chem. 279 (27): 28585–91. doi:10.1074/jbc.M312913200. PMID 15100233.  Liu D, Safari A, O'Connor MS, et al. (2004). "PTOP interacts with POT1 and regulates its localization to telomeres.". Nat. Cell Biol. 6 (7): 673–80. doi:10.1038/ncb1142. PMID 15181449.  Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.  Ye JZ, Donigian JR, van Overbeek M, et al. (2004). "TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.". J. Biol. Chem. 279 (45): 47264–71. doi:10.1074/jbc.M409047200. PMID 15316005.  Liu D, O'Connor MS, Qin J, Songyang Z (2005). "Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.". J. Biol. Chem. 279 (49): 51338–42. doi:10.1074/jbc.M409293200. PMID 15383534.  Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.  Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.  Antoine K, Ferbus D, Kolahgar G, et al. (2005). "Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1.". J. Cell. Biochem. 95 (4): 763–8. doi:10.1002/jcb.20487. PMID 15838871.  Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.  Wu Y, Zacal NJ, Rainbow AJ, Zhu XD (2007). "XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening.". DNA Repair (Amst.) 6 (2): 157–66. doi:10.1016/j.dnarep.2006.09.005. PMID 17055345.  Bae NS, Baumann P (2007). "A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends.". Mol. Cell 26 (3): 323–34. doi:10.1016/j.molcel.2007.03.023. PMID 17499040.  v · d · ePDB gallery 1fex: SOLUTION STRUCTURE OF MYB-DOMAIN OF HUMAN RAP1   This article on a gene on chromosome 16 is a stub. You can help Wikipedia by expanding it.v · d · e