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edit V-rel reticuloendotheliosis viral oncogene homolog B PDB rendering based on 1zk9. Available structures PDB 1zk9, 1zka Identifiers Symbols RELB; I-REL; IREL; REL-B External IDs OMIM: 604758 MGI: 103289 HomoloGene: 4747 GeneCards: RELB Gene Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • transcription corepressor activity • protein binding Cellular component • nucleus • cytosol Biological process • transcription, DNA-dependent • regulation of transcription, DNA-dependent • positive regulation of gene expression • antigen processing and presentation • myeloid dendritic cell differentiation • T-helper 1 cell differentiation Sources: Amigo / QuickGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5971 19698 Ensembl ENSG00000104856 ENSMUSG00000002983 UniProt Q01201 Q3U0K7 RefSeq (mRNA) NM_006509.3 NM_009046.2 RefSeq (protein) NP_006500.2 NP_033072.2 Location (UCSC) Chr 19: 45.5 - 45.54 Mb Chr 7: 20.19 - 20.21 Mb PubMed search [1] [2] Transcription factor RelB is a protein that in humans is encoded by the RELB gene.[1] Contents 1 Interactions 2 See also 3 Further reading 4 References Interactions RELB has been shown to interact with NFKB2[2][3] and NFKB1.[2] See also NF-κB Further reading Taylor JP, Pomerantz R, Bagasra O, et al. (1992). "TAR-independent transactivation by Tat in cells derived from the CNS: a novel mechanism of HIV-1 gene regulation.". EMBO J. 11 (9): 3395–403. PMC 556874. PMID 1505523.  Ruben SM, Klement JF, Coleman TA, et al. (1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity.". Genes Dev. 6 (5): 745–60. doi:10.1101/gad.6.5.745. PMID 1577270.  Liu J, Perkins ND, Schmid RM, Nabel GJ (1992). "Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription.". J. Virol. 66 (6): 3883–7. PMC 241175. PMID 1583734.  Biswas DK, Salas TR, Wang F, et al. (1996). "A Tat-induced auto-up-regulatory loop for superactivation of the human immunodeficiency virus type 1 promoter.". J. Virol. 69 (12): 7437–44. PMC 189681. PMID 7494249.  Jeang KT, Chun R, Lin NH, et al. (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor.". J. Virol. 67 (10): 6224–33. PMC 238044. PMID 7690421.  Alcamí J, Laín de Lera T, Folgueira L, et al. (1995). "Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes.". EMBO J. 14 (7): 1552–60. PMC 398242. PMID 7729429.  Majello B, De Luca P, Hagen G, et al. (1995). "Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1.". Nucleic Acids Res. 22 (23): 4914–21. doi:10.1093/nar/22.23.4914. PMC 523756. PMID 7800480.  Taylor JP, Pomerantz RJ, Oakes JW, et al. (1995). "A CNS-enriched factor that binds to NF-kappa B and is required for interaction with HIV-1 tat.". Oncogene 10 (2): 395–400. PMID 7838536.  Westendorp MO, Shatrov VA, Schulze-Osthoff K, et al. (1995). "HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.". EMBO J. 14 (3): 546–54. PMC 398112. PMID 7859743.  Scala G, Ruocco MR, Ambrosino C, et al. (1994). "The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein.". J. Exp. Med. 179 (3): 961–71. doi:10.1084/jem.179.3.961. PMC 2191426. PMID 8113688.  Bours V, Azarenko V, Dejardin E, Siebenlist U (1994). "Human RelB (I-Rel) functions as a kappa B site-dependent transactivating member of the family of Rel-related proteins.". Oncogene 9 (6): 1699–702. PMID 8183565.  Deloukas P, Dauwerse JG, van Ommen GJ, van Loon AP (1994). "The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kappa B is located on chromosome 11q12.". Genomics 19 (3): 592–4. doi:10.1006/geno.1994.1115. PMID 8188306.  Westendorp MO, Li-Weber M, Frank RW, Krammer PH (1994). "Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells.". J. Virol. 68 (7): 4177–85. PMC 236340. PMID 8207793.  Dobrzanski P, Ryseck RP, Bravo R (1993). "Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif.". Mol. Cell. Biol. 13 (3): 1572–82. PMC 359469. PMID 8441398.  Harhaj E, Blaney J, Millhouse S, Sun SC (1996). "Differential effects of I kappa B molecules on Tat-mediated transactivation of HIV-1 LTR.". Virology 216 (1): 284–7. doi:10.1006/viro.1996.0062. PMID 8615004.  Conant K, Ma M, Nath A, Major EO (1996). "Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes.". J. Virol. 70 (3): 1384–9. PMC 189957. PMID 8627654.  Demarchi F, d'Adda di Fagagna F, Falaschi A, Giacca M (1996). "Activation of transcription factor NF-kappaB by the Tat protein of human immunodeficiency virus type 1.". J. Virol. 70 (7): 4427–37. PMC 190376. PMID 8676466.  Beauparlant P, Kwon H, Clarke M, et al. (1996). "Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication.". J. Virol. 70 (9): 5777–85. PMC 190591. PMID 8709193.  Ramazzotti E, Vignoli M, Re MC, et al. (1996). "Enhanced nuclear factor-kappa B activation induced by tumour necrosis factor-alpha in stably tat-transfected cells is associated with the presence of cell-surface-bound Tat protein.". AIDS 10 (5): 455–61. doi:10.1097/00002030-199605000-00002. PMID 8724035.  References ^ Bours V, Burd PR, Brown K, Villalobos J, Park S, Ryseck RP, Bravo R, Kelly K, Siebenlist U (Feb 1992). "A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site". Mol Cell Biol 12 (2): 685–95. PMC 364259. PMID 1531086.  ^ a b Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (Feb. 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216.  ^ Thornburg, Natalie J; Pathmanathan Rajadurai, Raab-Traub Nancy (Dec. 2003). "Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma". Cancer Res. (United States) 63 (23): 8293–301. ISSN 0008-5472. PMID 14678988.  v · d · ePDB gallery 1zk9: NF-kB RelB forms an intertwined homodimer   1zka: NF-kB RelB forms an intertwined homodimer, Y300S mutant   v · d · eTranscription factors and intracellular receptors  (1) Basic domains (1.1) Basic leucine zipper (bZIP) Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) · AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) · BACH (1, 2) · BATF · BLZF1 · C/EBP (α, β, γ, δ, ε, ζ) · CREB (1, 3, L1) · CREM · DBP · DDIT3 · GABPA · HLF · MAF (B, F, G, K) · NFE (2, L1, L2, L3) · NFIL3 · NRL · NRF (1, 2, 3) · XBP1 (1.2) Basic helix-loop-helix (bHLH) ATOH1 · AhR · AHRR · ARNT · ASCL1 · BHLHB2 · BMAL (ARNTL, ARNTL2) · CLOCK · EPAS1 · FIGLA · HAND (1, 2) · HES (5, 6) · HEY (1, 2, L) · HES1 · HIF (1A, 3A) · ID (1, 2, 3, 4) · LYL1 · MESP2 · MXD4 · MYCL1 · MYCN · Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) · Neurogenins (1, 2, 3) · NeuroD (1, 2) · NPAS (1, 2, 3) · OLIG (1, 2) · Pho4 · Scleraxis · SIM (1, 2) · TAL (1, 2) · Twist · USF1 (1.3) bHLH-ZIP AP-4 · MAX · MITF · MNT · MLX · MXI1 · Myc · SREBP (1, 2) (1.4) NF-1 NFI (A, B, C, X) · SMAD (R-SMAD (1, 2, 3, 5, 9) - I-SMAD (6, 7) - 4) (1.5) RF-X RFX (1, 2, 3, 4, 5, ANK) (1.6) Basic helix-span-helix (bHSH) AP-2 (α, β, γ, δ, ε)  (2) Zinc finger DNA-binding domains (2.1) Nuclear receptor (Cys4) subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) subfamily 3 (Steroid hormone (Androgen, Estrogen (α, β), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related (α, β, γ)) subfamily 4 NUR (NGFIB, NOR1, NURR1) · subfamily 5 (LRH-1, SF1) · subfamily 6 (GCNF) · subfamily 0 (DAX1, SHP) (2.2) Other Cys4 GATA (1, 2, 3, 4, 5, 6) · MTA (1, 2, 3) · TRPS1 (2.3) Cys2His2 General transcription factors (TFIIA, TFIIB, TFIID, TFIIE (1, 2), TFIIF (1, 2), TFIIH (1, 2, 4, 2I, 3A, 3C1, 3C2)) ATBF1 · BCL (6, 11A, 11B) · CTCF · E4F1 · EGR (1, 2, 3, 4) · ERV3 · GFI1 · GLI-Krüppel family (1, 2, 3, REST, S2, YY1) · HIC (1, 2) · HIVEP (1, 2, 3) · IKZF (1, 2, 3) · ILF (2, 3) · KLF (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17) · MTF1 · MYT1 · OSR1 · PRDM9 · SALL (1, 2, 3, 4) · SP (1, 2, 4, 7, 8) · TSHZ3 · WT1 · Zbtb7 (7A, 7B) · ZBTB (16, 17, 20, 32, 33, 40) · zinc finger (3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 300, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 644, 649, 655) (2.4) Cys6 HIVEP1 (2.5) Alternating composition AIRE · DIDO1 · GRLF1 · ING (1, 2, 4) · JARID (1A, 1B, 1C, 1D, 2) · JMJD1B  (3) Helix-turn-helix domains (3.1) Homeodomain ARX · CDX (1, 2) · CRX · CUTL1 · DBX (1, 2)  · DLX (3, 4, 5) · EMX2 · EN (1, 2) · FHL (1, 2, 3) · HESX1 · HHEX · HLX · Homeobox (A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) · HOPX · IRX (1, 2, 3, 4, 5, 6, MKX) · LMX (1A, 1B) · MEIS (1, 2) · MEOX2 · MNX1 · MSX (1, 2) · NANOG · NKX (2-1, 2-2, 2-3, 2-5, 3-1, 3-2, 6-1, 6-2) · NOBOX · PBX (1, 2, 3) · PHF (1, 3, 6, 8, 10, 16, 17, 20, 21A) · PHOX (2A, 2B)  · PITX (1, 2, 3) · POU domain (PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) · OTX (1, 2) · PDX1 · SATB2 · SHOX2 · VAX1 · ZEB (1, 2) (3.2) Paired box PAX (1, 2, 3, 4, 5, 6, 7, 8, 9) (3.3) Fork head / winged helix E2F (1, 2, 3, 4, 5) · FOX proteins (A1, A2, A3, C1, C2, D3, D4, E1, E3, F1, G1, H1, J2, K1, K2, L2, M1, N1, N3, O1, O3, O4, P1, P2, P3, P4) (3.4) Heat Shock Factors HSF (1, 2, 4) (3.5) Tryptophan clusters ELF (2, 4, 5) · EGF · ELK (1, 3, 4) · ERF · ETS (1, 2, ERG, SPIB) · ETV (1, 4, 5, 6) · FLI1 · Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) · MYB · MYBL2 (3.6) TEA domain transcriptional enhancer factor (1, 2, 3, 4)  (4) β-Scaffold factors with minor groove contacts (4.1) Rel homology region NF-κB (NFKB1, NFKB2, REL, RELA, RELB) · NFAT (C1, C2, C3, C4, 5) (4.2) STAT STAT (1, 2, 3, 4, 5, 6) (4.3) p53 p53 · TBX (1, 2, 3, 5, 19, 21, 22, Brachyury, TBR1) (4.4) MADS box Mef2 (A, B, C, D) · SRF (4.6) TATA binding proteins TBP · TBPL1 (4.7) High-mobility group HMGB (1, 2, 3, 4) · HMGN (1, 2, 3, 4)  · HNF (1A, 1B) · LEF1 · SOX (1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) · SRY · SSRP1 · TCF (3, 4) · TOX (1, 2, 3, 4) (4.10) Cold-shock domain CSDA, YBX1 (4.11) Runt CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)   (0) Other transcription factors (0.2) HMGI(Y) HMGA (1, 2) · HBP1 (0.3) Pocket domain Rb · RBL1 · RBL2 (0.5) AP-2/EREBP-related factors Apetala 2 · EREBP · B3 (0.6) Miscellaneous ARID (1A, 1B, 2, 3A, 3B, 4A) · CAP · IFI (16, 35) · MLL (2, 3, T1) · MNDA · NFY (A, B, C) · Rho/Sigma see also transcription factor/coregulator deficiencies B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°) This article on a gene on chromosome 19 is a stub. 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