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In molecular biology, immunophilins are endogenous cytosolic peptidyl-prolyl isomerases that interconvert between the cis and trans positions. Immunophilins are targeted by immunosuppressive drugs such as rapamycin, ciclosporin, and tacrolimus. For these drugs in particular, known immunophilins such as cyclophilin catalyze the cis-trans isomerization of peptide bonds, particularly X-Pro peptide bonds. This isomerase activity can be inhibited by immunosuppressive drugs. See also FKBP12 FKBP52 FKBP5 = FKBP51 External links MeSH Immunophilins "Plant immunophilins and signal transduction" at v · d · eTransmembrane receptors: Immunoglobulin superfamily immune receptors Antibody receptor: Fc receptor Epsilon (ε) FcεRI · (FcεRII is C-type lectin) Gamma (γ) FcγRI · FcγRII · FcγRIII · Neonatal Alpha (α)/mu (μ) FcαRI · Fcα/μR Secretory Polymeric immunoglobulin receptor Antigen receptor B cells Antigen receptor BCR Co-receptor stimulate: CD21/CD19/CD81 inhibit: CD22 Accessory molecules Ig-α/Ig-β (CD79) T cells Ligands MHC (MHC class I and MHC class II) Antigen receptor TCR: TRA@ · TRB@ · TRD@ · TRG@ Co-receptors CD8 (with two glycoprotein chains CD8α and CD8β) · CD4 Accessory molecules CD3 · CD3γ · CD3δ · CD3ε · ζ-chain (also called CD3ζ and TCRζ) Cytokine receptor see cytokine receptors Killer-cell IG-like receptors KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DL5B, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KIR3DS1 Leukocyte IG-like receptors LILRA1 · LILRA2 · LILRA3 · LILRA4 · LILRA5 · LILRA6 · LILRB1 · LILRB2 · LILRB3 · LILRB4 · LILRB5 · LILRA6 · LILRA5 B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp) M: LMC cell/phys/auag/auab/comp, igrc imdf/ipig/hyps/tumr proc, drug(L3/4) This enzyme-related article is a stub. You can help Wikipedia by expanding it.v · d · e This immunology article is a stub. You can help Wikipedia by expanding it.v · d · e