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edit Inter-alpha (globulin) inhibitor H2 Identifiers Symbols ITIH2; H2P; SHAP External IDs OMIM: 146640 MGI: 96619 HomoloGene: 1668 GeneCards: ITIH2 Gene Gene Ontology Molecular function • serine-type endopeptidase inhibitor activity Cellular component • extracellular region Biological process • hyaluronan metabolic process Sources: Amigo / QuickGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3698 16425 Ensembl ENSG00000151655 ENSMUSG00000037254 UniProt P19823 Q3UZM0 RefSeq (mRNA) NM_002216 NM_010582 RefSeq (protein) NP_002207 NP_034712 Location (UCSC) Chr 10: 7.79 - 7.83 Mb Chr 2: 10.01 - 10.05 Mb PubMed search [1] [2] Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.[1][2][3] See also Inter-alpha-trypsin inhibitor ITIH1 ITIH3 ITIH4 References ^ Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.  ^ Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603.  ^ "Entrez Gene: ITIH2 inter-alpha (globulin) inhibitor H2".  Further reading Malki N, Balduyck M, Maes P, et al. (1992). "The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A.". Biol. Chem. Hoppe-Seyler 373 (10): 1009–18. PMID 1384548.  Salier JP, Diarra-Mehrpour M, Sesboue R, et al. (1988). "Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI.". Proc. Natl. Acad. Sci. U.S.A. 84 (23): 8272–6. doi:10.1073/pnas.84.23.8272. PMC 299524. PMID 2446322.  Gebhard W, Schreitmüller T, Hochstrasser K, Wachter E (1988). "Complementary DNA and derived amino acid sequence of the precursor of one of the three protein components of the inter-alpha-trypsin inhibitor complex.". FEBS Lett. 229 (1): 63–7. doi:10.1016/0014-5793(88)80798-1. PMID 2450046.  Salier JP, Diarra-Mehrpour M, Sesboüé R, et al. (1989). "Human inter-alpha-trypsin inhibitor. Isolation and characterization of heavy (H) chain cDNA clones coding for a 383 amino-acid sequence of the H chain.". Biol. Chem. Hoppe-Seyler 369 Suppl: 15–8. PMID 2462430.  Diarra-Mehrpour M, Bourguignon J, Sesboüé R, et al. (1989). "Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes.". Eur. J. Biochem. 179 (1): 147–54. doi:10.1111/j.1432-1033.1989.tb14532.x. PMID 2465147.  Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G (1989). "Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan.". J. Biol. Chem. 264 (27): 15975–81. PMID 2476436.  Schreitmüller T, Hochstrasser K, Reisinger PW, et al. (1987). "cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins.". Biol. Chem. Hoppe-Seyler 368 (8): 963–70. PMID 3663330.  Huang L, Yoneda M, Kimata K (1994). "A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor.". J. Biol. Chem. 268 (35): 26725–30. PMID 7504674.  Morelle W, Capon C, Balduyck M, et al. (1994). "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor.". Eur. J. Biochem. 221 (2): 881–8. doi:10.1111/j.1432-1033.1994.tb18803.x. PMID 7513643.  Wisniewski HG, Burgess WH, Oppenheim JD, Vilcek J (1994). "TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor.". Biochemistry 33 (23): 7423–9. doi:10.1021/bi00189a049. PMID 7516184.  Enghild JJ, Salvesen G, Thøgersen IB, et al. (1993). "Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin.". J. Biol. Chem. 268 (12): 8711–6. PMID 7682553.  Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  Mizon C, Balduyck M, Albani D, et al. (1996). "Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains.". J. Immunol. Methods 190 (1): 61–70. doi:10.1016/0022-1759(95)00257-X. PMID 8601712.  Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  Olsen EH, Rahbek-Nielsen H, Thogersen IB, et al. (1998). "Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2.". Biochemistry 37 (1): 408–16. doi:10.1021/bi971137d. PMID 9425062.  Mizushima S, Nii A, Kato K, Uemura A (1998). "Gene expression of the two heavy chains and one light chain forming the inter-alpha-trypsin-inhibitor in human tissues.". Biol. Pharm. Bull. 21 (2): 167–9. PMID 9514613.  Flahaut C, Capon C, Balduyck M, et al. (1998). "Glycosylation pattern of human inter-alpha-inhibitor heavy chains.". Biochem. J. 333 ( Pt 3): 749–56. PMC 1219641. PMID 9677337.  Hamm A, Veeck J, Bektas N, et al. (2008). "Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysis.". BMC Cancer 8 (25): 25. doi:10.1186/1471-2407-8-25. PMC 2268946. PMID 18226209.  This article on a gene on chromosome 10 is a stub. You can help Wikipedia by expanding it.v · d · e