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lysine-tRNA ligase Identifiers EC number CAS number 9031-26-9 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a lysine-tRNA ligase (EC is an enzyme that catalyzes the chemical reaction ATP + L-lysine + tRNALys AMP + diphosphate + L-lysyl-tRNALys The 3 substrates of this enzyme are ATP, L-lysine, and tRNA(Lys), whereas its 3 products are AMP, diphosphate, and L-lysyl-tRNA(Lys). This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-lysine:tRNALys ligase (AMP-forming). Other names in common use include lysyl-tRNA synthetase, lysyl-transfer ribonucleate synthetase, lysyl-transfer RNA synthetase, L-lysine-transfer RNA ligase, lysine-tRNA synthetase, and lysine translase. This enzyme participates in 3 metabolic pathways: lysine biosynthesis, aminoacyl-trna biosynthesis, and amyotrophic lateral sclerosis (als). References ALLEN EH, GLASSMAN E, SCHWEET RS (1960). "Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes". J. Biol. Chem. 235: 1061–7. PMID 13792726.  Chlumecka V, Von Tigerstrom M, D'Obrenan P, Smith CJ (1969). "Purification and properties of lysyl transfer ribonucleic acid synthetase from bakers' yeast". J. Biol. Chem. 244 (20): 5481–8. PMID 4310598.  Lagerkvist U, Rymo L, Lindqvist O, Andersson E (1972). "Some properties of crystals of lysine transfer ribonucleic acid ligase from yeast". J. Biol. Chem. 247 (12): 3897–9. PMID 4555953.  Stern R, Mehler AH (1965). "Lysyl-sRNA synthetase from Escherichia coli". Biochem. Z. 342 (4): 400–9. PMID 4284804.  This ligase article is a stub. You can help Wikipedia by expanding it. v • d • e v • d • e Enzymes: ligases (EC 6) 6.1: Carbon-Oxygen Aminoacyl tRNA synthetase (tyrosine-tRNA ligase, tryptophan-tRNA ligase, threonine-tRNA ligase, leucine-tRNA ligase, isoleucine-tRNA ligase, lysine-tRNA ligase, alanine-tRNA ligase, valine-tRNA ligase, methionine-tRNA ligase, serine-tRNA ligase, aspartate-tRNA ligase, D-alanine-poly(phosphoribitol) ligase, glycine-tRNA ligase, proline-tRNA ligase, cysteine-tRNA ligase, glutamate-tRNA ligase, glutamine-tRNA ligase, arginine-tRNA ligase, phenylalanine-tRNA ligase, histidine-tRNA ligase, asparagine-tRNA ligase, aspartate-tRNAAsn ligase, glutamate-tRNAGln ligase, lysine-tRNAPyl ligase) 6.2: Carbon-Sulfur Succinyl coenzyme A synthetase - Acetyl Co-A synthetase - Long fatty acyl CoA synthetase 6.3: Carbon-Nitrogen Glutamine synthetase - Ubiquitin ligase (Von Hippel-Lindau tumor suppressor, UBE3A, Mdm2, Anaphase-promoting complex) - Glutathione synthetase - CTP synthase - Adenylosuccinate synthase - Argininosuccinate synthetase - Holocarboxylase synthetase - GMP synthase - Asparagine synthetase - Carbamoyl phosphate synthetase (I, II) - Gamma-glutamylcysteine synthetase 6.4: Carbon-Carbon Carbon-carbon ligases 6.5: Phosphoric Ester DNA ligase 6.6: Nitrogen-Metal Magnesium chelatase - Cobaltochelatase