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Small Cajal body specific RNA 14 Type: Gene; snRNA; snoRNA; scaRNA; 2° structure: Predicted; RNAalifold Seed alignment: Marantidis E, INFERNAL Avg length: 129.30 nucleotides Avg identity: 74.00% Small Cajal body specific RNAs (scaRNAs) are a specific class of small nuclear RNAs which localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1][2] U100 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure and the conserved H/ACA-box motifs.[3] U100 is the human orthologue of mouse H/ACA snoRNA MBII-201 identified in[4] and also included in this family. U100 is predicted to guide the pseudouridylation of U2 snRNA at residue U7.[5] References ^ Darzacq, X; Jady BE, Verheggen C, Kiss AM, Bertrand E, Kiss T (2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". EMBO J. 21 (11): 2746–2756. doi:10.1093/emboj/21.11.2746. PMC 126017. PMID 12032087.  ^ Lestrade, L; Weber MJ (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34 (Database issue): D158–D162. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.  ^ Vitali, P; Royo H, Seitz H, Bachellerie JP, Huttenhofer A, Cavaille J (2003). "Identification of 13 novel human modification guide RNAs". Nucleic Acids Res. 31 (22): 6543–6551. doi:10.1093/nar/gkg849. PMC 275545. PMID 14602913.  ^ Huttenhofer, A; Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". EMBO J. 20 (11): 2943–2953. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.  ^ Schattner, P; Barberan-Soler S, Lowe TM (2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA. 12 (1): 15–25. doi:10.1261/rna.2210406. PMC 1370881. PMID 16373490.  External links Rfam page for Small Cajal body specific RNA 14 This molecular or cell biology article is a stub. You can help Wikipedia by expanding it.v · d · e v · d · eSmall Cajal body-specific RNA 1 · 4 · 6 · 8 · 11 · 13 · 14 · 15 · 16 · 17 · 18 · 20 · 21 · 23 · 24 · 25