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edit RAS guanyl releasing protein 2 (calcium and DAG-regulated) Identifiers Symbols RASGRP2; CDC25L; CALDAG-GEFI External IDs OMIM: 605577 MGI: 1333849 HomoloGene: 4250 GeneCards: RASGRP2 Gene Gene Ontology Molecular function • guanyl-nucleotide exchange factor activity • Ras guanyl-nucleotide exchange factor activity • calcium ion binding • kinase activity • diacylglycerol binding Cellular component • intracellular • cytosol • plasma membrane Biological process • regulation of cell growth • Ras protein signal transduction • regulation of small GTPase mediated signal transduction RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 10235 19395 Ensembl ENSG00000068831 ENSMUSG00000032946 UniProt n/a n/a RefSeq (mRNA) NM_005825 NM_011242 RefSeq (protein) NP_005816 NP_035372 Location (UCSC) Chr 11: 64.25 - 64.27 Mb Chr 19: 6.4 - 6.42 Mb PubMed search [1] [2] RAS guanyl-releasing protein 2 is a protein that in humans is encoded by the RASGRP2 gene.[1][2] The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Two alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been reported.[2] References ^ Kawasaki H, Springett GM, Toki S, Canales JJ, Harlan P, Blumenstiel JP, Chen EJ, Bany IA, Mochizuki N, Ashbacher A, Matsuda M, Housman DE, Graybiel AM (Nov 1998). "A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia". Proc Natl Acad Sci U S A 95 (22): 13278–83. doi:10.1073/pnas.95.22.13278. PMID 9789079.  ^ a b "Entrez Gene: RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10235.  Further reading Kedra D, Seroussi E, Fransson I, et al. (1997). "The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13.". Hum. Genet. 100 (5-6): 611–9. doi:10.1007/s004390050562. PMID 9341881.  Clyde-Smith J, Silins G, Gartside M, et al. (2000). "Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor.". J. Biol. Chem. 275 (41): 32260–7. doi:10.1074/jbc.M006087200. PMID 10918068.  Guo FF, Kumahara E, Saffen D (2001). "A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2.". J. Biol. Chem. 276 (27): 25568–81. doi:10.1074/jbc.M101277200. PMID 11292831.  Toki S, Kawasaki H, Tashiro N, et al. (2001). "Guanine nucleotide exchange factors CalDAG-GEFI and CalDAG-GEFII are colocalized in striatal projection neurons.". J. Comp. Neurol. 437 (4): 398–407. doi:10.1002/cne.1291. PMID 11503142.  Eto K, Murphy R, Kerrigan SW, et al. (2002). "Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12819–24. doi:10.1073/pnas.202380099. PMID 12239348.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  Katagiri K, Shimonaka M, Kinashi T (2004). "Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1.". J. Biol. Chem. 279 (12): 11875–81. doi:10.1074/jbc.M310717200. PMID 14702343.  Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  This article on a gene on chromosome 11 is a stub. You can help Wikipedia by expanding it. v • d • e