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This article is an orphan, as few or no other articles link to it. Please introduce links to this page from related articles; suggestions may be available. (February 2009) edit L(3)mbt-like (Drosophila) PDB rendering based on 1oyx. Available structures PDB 1oyx, 1oz2, 1oz3 Identifiers Symbols L3MBTL; DKFZp586P1522; FLJ41181; H-L(3)MBT; KIAA0681; L3MBTL1; dJ138B7.3 External IDs OMIM: 608802 MGI: 2676663 HomoloGene: 41846 GeneCards: L3MBTL Gene Gene Ontology Molecular function • transcription factor activity • zinc ion binding • metal ion binding Cellular component • nucleus Biological process • regulation of transcription, DNA-dependent • chromatin modification Sources: Amigo / QuickGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 26013 241764 Ensembl ENSG00000185513 ENSMUSG00000035576 UniProt Q9Y468 n/a RefSeq (mRNA) NM_015478 XM_895109 RefSeq (protein) NP_056293 XP_900202 Location (UCSC) Chr 20: 41.58 - 41.6 Mb Chr 2: 162.64 - 162.67 Mb PubMed search [1] [2] Lethal(3)malignant brain tumor-like protein is a protein that in humans is encoded by the L3MBTL gene.[1][2][3] This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.[3] References ^ Koga H, Matsui S, Hirota T, Takebayashi S, Okumura K, Saya H (Sep 1999). "A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes". Oncogene 18 (26): 3799–809. doi:10.1038/sj.onc.1202732. PMID 10445843.  ^ Trojer P, Li G, Sims RJ 3rd, Vaquero A, Kalakonda N, Boccuni P, Lee D, Erdjument-Bromage H, Tempst P, Nimer SD, Wang YH, Reinberg D (Jun 2007). "L3MBTL1, a histone-methylation-dependent chromatin lock". Cell 129 (5): 915–28. doi:10.1016/j.cell.2007.03.048. PMID 17540172.  ^ a b "Entrez Gene: L3MBTL l(3)mbt-like (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26013.  Further reading Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.  MacGrogan D, Kalakonda N, Alvarez S, et al. (2004). "Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells". Genes Chromosomes Cancer 41 (3): 203–13. doi:10.1002/gcc.20087. PMID 15334543.  Li J, Bench AJ, Vassiliou GS, et al. (2004). "Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies". Proc. Natl. Acad. Sci. U.S.A. 101 (19): 7341–6. doi:10.1073/pnas.0308195101. PMC 409920. PMID 15123827.  Wang WK, Tereshko V, Boccuni P, et al. (2004). "Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets". Structure 11 (7): 775–89. doi:10.1016/S0969-2126(03)00127-8. PMID 12842041.  Boccuni P, MacGrogan D, Scandura JM, Nimer SD (2003). "The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)". J. Biol. Chem. 278 (17): 15412–20. doi:10.1074/jbc.M300592200. PMID 12588862.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.  Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.  Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.  v · d · ePDB gallery 1oyx: CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (SELENO-MET) AT 1.85 ANGSTROM   1oz2: CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (NATIVE-II) AT 1.55 ANGSTROM   1oz3: Crystal Structure of 3-MBT repeats of lethal (3) malignant Brain Tumor (Native-I) at 1.85 angstrom   This article on a gene on chromosome 20 is a stub. You can help Wikipedia by expanding it.v · d · e