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Connective Tissue is a form of fibrous tissue.[1]. It is one of the four types of tissue in traditional classifications (the others being epithelial, muscle, and nervous tissue). Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals, making up about 25% of the total protein content.[2] Contents 1 Fiber types and characteristics of the connective tissue 2 Mechanics 3 Disorders of connective tissue 4 Staining of connective tissue 5 References 6 External links // Fiber types and characteristics of the connective tissue Not caca `en t Matrix - non-living material for the nourishing of cells Fibers Mechanics Connective tissues have mechanical characteristics of soft tissue. They aid in major packing material, organ framework, provide lubrication, and in the passage of blood vessels and nerves. Disorders of connective tissue Main article: Connective tissue disease Various connective tissue conditions have been identified; these can be both inherited and environmental. Marfan syndrome - a genetic disease causing abnormal fibrillin. Scurvy - caused by a dietary deficiency in vitamin C, leading to abnormal collagen. Ehlers-Danlos syndrome - deficient type III collagen- a genetic disease causing progressive deterioration of collagens, with different EDS types affecting different sites in the body, such as joints, heart valves, organ walls, arterial walls, etc. Loeys-Dietz syndrome - a genetic disease related to Marfan syndrome, with an emphasis on vascular deterioration. Pseudoxanthoma elasticum - an autosomal recessive hereditary disease, caused by calcification and fragmentation of elastic fibres, affecting the skin, the eyes and the cardiovascular system. Systemic lupus erythematosus - a chronic, multisystem, inflammatory disorder of probable autoimmune etiology, occurring predominantly in young women. Osteogenesis imperfecta (brittle bone disease) - caused by insufficient production of good quality collagen to produce healthy, strong bones. Fibrodysplasia ossificans progressiva - disease of the connective tissue, caused by a defective gene which turns connective tissue into bone. Spontaneous pneumothorax - collapsed lung, believed to be related to subtle abnormalities in connective tissue. Sarcoma - a neoplastic process originating within connective tissue. Staining of connective tissue For microscopic viewing, the majority of the connective tissue staining techniques color tissue fibers in contrasting shades. Collagen may be differentially stained by any of the following techniques: Van Gieson's stain Masson's Trichrome stain Mallory's Aniline Blue stain Azocarmine stain Krajian's Aniline Blue stain References ^ connective tissue at Dorland's Medical Dictionary ^ Di Lullo, G. A. (2002). "Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen". Journal of Biological Chemistry 277 (6): 4223. doi:10.1074/jbc.M110709200. PMID 11704682. http://www.jbc.org/cgi/content/abstract/277/6/4223.  External links connective+tissue at eMedicine Dictionary Encyclopaedia Britannica, Connective Tissue Overview at kumc.edu UIUC Histology Subject 230 Connective tissue atlas at uiowa.edu v • d • e Biological tissue Animals Epithelium - Connective - Muscular - Nervous Plants Dermal - Vascular - Ground v • d • e Histology: connective tissue Classification Proper/ Fibrous Loose Areolar · Reticular non-fibrous: Adipose (Brown, White) Dense Dense irregular connective tissue (Submucosa, Dermis) · Dense regular connective tissue (Ligament, Tendon, Aponeurosis) Embryonic Mucous · Mesenchymal Specialized Cartilage · Bone · Blood Composition Extracellular matrix (noncellular) Ground substance Tissue fluid Fibers Reticular fibers: Collagen Elastic fibers: Fibrillin (FBN1, FBN2, FBN3) Cells Resident Fibroblast · Reticular cell · Tendon cell Adipocyte Chondroblast · Osteoblast Wandering cell Mast cell · Macrophage see also soft tissue M: INT, SF, LCT anat/phys/devp noco(i,b,d,q,u,r,p,k,c,v)/cong/tumr(n,e,d), sysi/epon proc, drug (D2/3/4/5/8) M: MUS, DF+DRCT anat (h/n, u, t/d, a/p, l)/phys/hist noco(m, s, c)/cong(d)/tumr, sysi/epon, injr proc, drug (M1A/3)