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edit Protein tyrosine phosphatase, receptor type, H Identifiers Symbols PTPRH; FLJ39938; MGC133058; MGC133059; SAP-1 External IDs OMIM: 602510 HomoloGene: 37693 GeneCards: PTPRH Gene Gene Ontology Molecular function • protein tyrosine phosphatase activity • receptor activity • transmembrane receptor protein tyrosine phosphatase activity • hydrolase activity Cellular component • integral to plasma membrane • integral to membrane Biological process • protein amino acid dephosphorylation RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5794 545902 Ensembl ENSG00000080031 ENSMUSG00000035429 UniProt n/a n/a RefSeq (mRNA) NM_002842 XM_620401 RefSeq (protein) NP_002833 XP_620401 Location (UCSC) Chr 19: 60.38 - 60.41 Mb Chr 7: 4.15 - 4.21 Mb PubMed search [1] [2] Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene.[1][2] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues.[2] References ^ Matozaki T, Suzuki T, Uchida T, Inazawa J, Ariyama T, Matsuda K, Horita K, Noguchi H, Mizuno H, Sakamoto C, et al. (Feb 1994). "Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers". J Biol Chem 269 (3): 2075–81. PMID 8294459.  ^ a b "Entrez Gene: PTPRH protein tyrosine phosphatase, receptor type, H". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5794.  Further reading Noguchi T, Tsuda M, Takeda H, et al. (2001). "Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas.". J. Biol. Chem. 276 (18): 15216–24. doi:10.1074/jbc.M007208200. PMID 11278335.  Marneros AG, Mehenni H, Reichenberger E, et al. (2001). "Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome.". Cytogenet. Cell Genet. 92 (3-4): 213–6. doi:10.1159/000056905. PMID 11435690.  Takada T, Noguchi T, Inagaki K, et al. (2002). "Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1.". J. Biol. Chem. 277 (37): 34359–66. doi:10.1074/jbc.M206541200. PMID 12101188.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.  Nagano H, Noguchi T, Inagaki K, et al. (2003). "Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma.". Oncogene 22 (30): 4656–63. doi:10.1038/sj.onc.1206588. PMID 12879010.  Pasquali C, Curchod ML, Wälchli S, et al. (2004). "Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor.". Mol. Endocrinol. 17 (11): 2228–39. doi:10.1210/me.2003-0011. PMID 12907755.  Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.  This article on a gene on chromosome 19 is a stub. You can help Wikipedia by expanding it.v · d · e v · d · eEsterase: protein tyrosine phosphatases (EC 3.1.3.48) Class I Classical PTPs Receptor type PTPs (PTPRA, PTPRB, PTPRC, PTPRD, PTPRE, PTPRF, PTPRG, PTPRH, PTPRJ, PTPRK, PTPRM, PTPRN, PTPRN2, PTPRO, PTPRQ, PTPRR, PTPRS, PTPRT, PTPRU, PTPRZ) Non receptor type PTPs (PTPN1, PTPN2, PTPN3, PTPN4, PTPN5, PTPN6, PTPN7, PTPN9, PTPN11, PTPN12, PTPN13, PTPN14, PTPN18, PTPN20, PTPN21, PTPN22, PTPN23 VH1-like or dual specific phosphatases (DSPs) MAPK phosphatases (MKPs) (DUSP1, DUSP2, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, DUSP10, DUSP16, MK-STYX) Slingshots (SSH1, SSH2, SSH3) PRLs (PTP4A1, PTP4A2, PTP4A3) CDC14s (CDC14A, CDC14B, CDKN3, PTP9Q22) Atypical DSPs (DUSP3, DUSP11, DUSP12, DUSP13A, DUSP13B, DUSP14, DUSP15, DUSP18, DUSP19, DUSP21, DUSP22, DUSP23, DUSP24, DUSP25, DUSP26, DUSP27, EMP2A, RNGTT, STYX) Phosphatase and tensin homologs (PTENs) (PTEN, TPIP, TPTE, TNS, TENC1) Myotubularins (MTM1, MTMR2, MTMR3, MTMR4, MTMR5, MTMR6, MTMR7, MTMR8, MTMR9, MTMR10, MTMR11, MTMR12, MTMR13, MTMR14, MTMR15) Class II ACP1 Class III Cdc25: CDC25A, CDC25B, CDC25C Class IV Eyes absent homolog (EYA1, EYA2, EYA3, EYA4) B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6