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HLA-Cw7 (MHC Class I, C cell surface antigen) - Protein transmembrane receptor/ligand Structure αβ heterodimer Subunits HLA-Cw*07--, β2-microglobulin Older names "-" - subtype allele Available structures Cw7 *0701 - *0702 Alleles link-out to IMGT/HLA database at EBI HLA-Cw7 (Cw7) is a human leukocyte antigen serotype within HLA-C serotype group. The serotype is determined by the antibody recognition of α7 subset of HLA-Cw α-chains. For Cw7, the alpha chain are encoded by the HLA-Cw*07 allele group and the β-chain are encoded by B2M locus.[1] Cw7 and Cw*07 are almost synonymous in meaning. Further information: HLA serotypes explained Cw7 is more common in West Africa to Ireland. Cw7 in Europe is part of the AH8.1 and HLA B7-DR15-DQ6 haplotypes. The class I region of these supertype is HLA A1-B8 haplotype, HLA A3-B7, HLA-A2-B7 and HLA A24-B7. Serotype Cw7 recognition of some HLA Cw*07 gene products[2] Cw*07 Cw7 Sample allele  % size (N) *0701 74 304 *0702 68 976 Distribution HLA Cw*0701 frequencies  Study population  Freq.  (in %)[3]  Cameroon Pygmy Baka   25.0  Ireland South   21.2  German Essen   20.9  Cameroon Sawa   19.2  Ireland Northern   18.7  France West   18.1  Kenya   17.8  Burkina Faso Fulani   17.4  Australia New South Wales   17.3  France South East   17.3  Morocco 'Berber' Nador Me…   16.7  Sudanese   16.5  United Kingdom Caucasians   16.1  Uganda Kampala   16.0  Brazil   15.6  USA Caucasian (2)   15.5  Kenya Nandi   15.2  Pakistan Baloch   15.2  Burkina Faso Rimaibe   14.9  Finland   14.4  Czech Republic   14.2  Swiss Geneva   13.6  South Africa Natal Tamil   13.5  Cameroon Bamileke   13.0  India Khandesh Pawra   13.0  Cameroon Beti   12.9  Tunisia   12.6  India New Delhi   12.5  Saudi Arabia Guraiat and …   12.3  Turkey   12.3  Zambia Lusaka   12.2  Kenya Luo   11.7  Burkina Faso Mossi   11.3  South Korea (1)   11.1  Spain Eastern Andalusia   11.0  USA Hispanic   10.9  Lebanon   10.8  India Tamil Nadu Nadar   10.7  Zimbabwe Harare Shona   10.6  Russia Arkhangelsk Pomors   10.0  Georgia Tibilisi Georgian…   9.8  Mexico Zaptotec Oaxaca   9.7  Israel Arab Druse   9.0  Senegal Niokholo Mandenka   8.7  USA North American Native…   8.6  Pakistan Sindhi   8.3  India North Delhi   8.0  Iran Baloch   7.8  Thailand   7.7  Singapore Riau Malay   7.5  India West Coast Parsis   7.0  Georgia Tibilisi Kurds   6.9  Pakistan Kalash   6.5  Mali Bandiagara   6.2  Pakistan Burusho   5.6  Pakistan Karachi Parsi   5.5  Pakistan Pathan   5.5  Russia Murmansk Saomi   4.0  Singapore Javanese Indone…   4.0  India Mumbai Marathas   3.7  Australia Indig. Cape Yor…   3.4  Pakistan Brahui   3.4  India West Bhils   3.0  China North Han   2.9  Jordan Amman   2.8  China Inner Mongolia   2.5  Italy North Pavia   2.5  Russia Nenets   2.4  China Qinghai Hui   2.3  Australia Indig. Groote E…   2.1  Russia Tuva (2)   2.0  USA Hawaii Okinawa   1.9  USA Asian   1.8  China South Han   1.6  China Beijing   1.5  Papua New Guinea Wanigela   1.4 Allele frequencies presented, only HLA Cw*0702 frequencies  Study population  Freq.  (in %)[3]  Venezuela Sierra de Perij…   71.4  PNG New Britain Rabaul   57.1  Mexico Mixtec Oaxaca   33.3  China Yunnan Lisu   32.9  Taiwan Taroko   31.8  China Yunnan Nu   30.7  Venezuela Perja Mountain …   30.3  PNG Madang   30.2  Mexico Zaptotec Oaxaca   28.4  Taiwan Tsou   27.5  Mexico Mixe Oaxaca   26.4  Russia Arkhangelsk Pomors   26.0  Ch. Guangdong Meizhou H…   25.8  Pakistan Burusho   25.5  USA South Dakota Lakota S…   24.4  Russia Nenets   23.8  USA New Mexico Canoncito …   23.2  China South Han   20.8  Brazil Terena   20.2  China Guangzhou   19.9  USA Asian   19.5  Ireland Northern   18.6  Swiss Geneva   18.2  Taiwan Bunun   17.8  Ireland South   17.4  Singapore Javanese Indone…   17.0  Philippines Ivatan   16.0  Taiwan Rukai   16.0  Australia New South Wales   15.8  Finland   15.6  USA South Texas Hispanics   15.6  Pakistan Sindhi   15.5  United Kingdom Caucasians   15.5  Saudi Arabia Guraiat and …   15.2  Cameroon Pygmy Baka   15.0  India Tamil Nadu Nadar   14.8  Japan Central   14.6  Russia Murmansk Saomi   14.0  USA Hawaii Okinawa   13.8  China Beijing   13.6  China Tibetan   13.3  China Qinghai Hui   13.2  Thailand   13.0  USA North American Native…   12.8  China Inner Mongolia   12.7  Japan (3)   12.7  Pakistan Brahui   12.5  PNG Wanigela   12.5  USA Caucasian pop2   12.5  USA Hispanic   12.4  Czech Republic   12.3  China North Han   11.9  Taiwan Paiwan   11.8  China Wuhan   11.6  Cameroon Sawa   11.5  Taiwan Siraya   10.8  Taiwan Ami   10.7  New Caledonia   10.0  India North Delhi   9.9  Australia Indig. Cape Yor…   9.6  Pakistan Pathan   9.5  France West   9.4  Iran Baloch   9.4  South Africa Natal Tamil   9.4  German Essen   9.1  Taiwan Puyuma   9.0  India New Delhi   8.9  Pakistan Kalash   8.7  India Mumbai Marathas   8.6  Russia Tuva pop 2   8.6  South Korea (3)   8.3  American Samoa   8.0  Brazil   8.0  USA African American   8.0  France South East   7.2  Cameroon Bamileke   7.1  India West Bhils   7.0  Australia Indig. Yuendumu   6.8  Cameroon Beti   6.6  Georgia Tibilisi Georgian…   6.5  Uganda Kampala   6.1  Turkey   6.0  Spain Eastern Andalusia   5.5  PNG Wosera   5.4  Mali Bandiagara   4.7  Zimbabwe Harare Shona   4.6  Mexico Chihuahua State Ta…   4.5  Pakistan Baloch   4.5  Kenya   4.4  Zambia Lusaka   4.4  Lebanon   4.1  Israel Arab Druse   4.0  Kenya Luo   3.8  Tunisia   3.6  PNG Eastern Highlands Gor…   3.5  Sudanese   3.5  Georgia Tibilisi Kurds   3.4  Morocco 'Berber' Nador Me…   3.2  England London Ashkenazi …   2.9 Allele frequencies presented, only References ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.  ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute ^ a b Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.  v · d · eHLA-Cw serotypes and allele groups HLA-C · Cw1 (Cw11) · Cw2 · Cw3 (Cw9 · Cw10) · Cw4 · Cw5 · Cw6 · Cw7 · Cw8 · Cw*12 · Cw*13 · Cw*14 · Cw*15 · Cw*16 · Cw*17 · Cw*18