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Haplogroup U Possible time of origin 55,000 BP Possible place of origin Western Asia Ancestor R Descendants U1, U5, U6, U2'3'4'7'8'9 Defining mutations 11467, 12308, 12372[1] In human mitochondrial genetics, Haplogroup U is a human mitochondrial DNA (mtDNA) haplogroup. Contents 1 Origins 2 Distribution 3 Subclades 3.1 Haplogroup U1 3.2 Haplogroup U2 3.3 Haplogroup U3 3.4 Haplogroup U4 3.5 Haplogroup U5 3.6 Haplogroup U6 3.7 Haplogroup U7 3.8 Haplogroup U8 3.8.1 Haplogroup K 4 Tree 5 See also 6 References 7 External links Origins Haplogroup U descends from a woman in the Haplogroup R (mtDNA) branch of the phylogenetic tree, who lived around 55,000 years ago. Her descendants gave birth to several different subgroups, some of which exhibit specific geographic homelands. Distribution Haplogroup U is subdivided into Haplogroups U1-U8. Haplogroup K is a subclade of U8.[2] The old age has led to a wide distribution of the descendant subgroups that harbor specific European, Berber, Indian, African, Arab, northern Caucasus Mountains and the Near East clades.[3] Subclades Haplogroup U1 Haplogroup U1 (named 'Una' by Bryan Sykes) seems to appear mostly in the Middle East, however low frequency results appear scattered throughout Europe particularly in the Mediterranean. U1a in particular is found from India to Europe, but is extremely rare among the northern and Atlantic fringes of Europe including the British Isles and Scandinavia. Several examples in Tuscany have been noted. In India U1a has been found in the Kerala region. U1b has a similar spread but is rarer than U1a. Some examples of U1b have been found among Jewish diaspora. U1a and U1b appear in equal frequency in eastern Europe.[4] Haplogroup U2 Haplogroup U2 (named 'Uta' by Bryan Sykes) is most common in South Asia[5] but also found in low frequency in Central and West Asia, as well as in Europe as U2e.[6] This haplogroup has been found in the remains of a 30,000-year-old hunter-gatherer in South European Russia (Kostenki).[7] Haplogroup U3 Haplogroup U3 (named 'Uma' by Bryan Sykes) is defined by the HVR1 transition A16343G. It is found at low levels throughout Europe (about 1% of the population), the Near East (about 2.5% of the population), and Central Asia (1%). U3 is present at higher levels among populations in the Caucasus (about 6%) and among Lithuanian Romani, Polish Romani, and Spanish Romani populations (36-56%).[8][9][10] Haplogroup U4 Haplogroup U4 (named 'Ulrike' by Bryan Sykes) has its origin in the Upper Palaeolithic, dating to approximately 25,000 years ago. It is widely distributed in Europe, and has been implicated in the expansion of modern humans into Europe occurring before the Last Glacial Maximum. Haplogroup U5 Among the oldest mtDNA haplogroups found in European remains of Homo sapiens is U5. The age of U5 is estimated at 50,000 but could be as old as 60,500 years. Approximately 11% of total Europeans and 10% of European-Americans are in haplogroup U5. The presence of haplogroup U5 in Europe pre-dates the expansion of agriculture in Europe. Bryan Sykes' popular book The Seven Daughters of Eve calculated that it arose 45,000-50,000 years ago in Delphi, Greece and named the originator of haplogroup U5 Ursula. However the details related to location and age are speculative. Barbujani and Bertorelle estimate the age of haplogroup U5 as about 52,000 years ago, being the oldest subclade of haplogroup U.[11] Thus, the name 'Ursula' could be applied to the entirety of haplogroup U, as well as U5. U5 has been found in human remains dating from the Mesolithic in England, Germany, Lithuania, Poland, Portugal and Russia.[12] Haplogroup U5 and its subclades U5a and U5b form the highest population concentrations in the far north, in Sami, Finns, and Estonians, but it is spread widely at lower levels throughout Europe. This distribution, and the age of the haplogroup, indicate individuals from this haplogroup were part of the initial expansion tracking the retreat of ice sheets from Europe ~10kya. Haplogroup U5 is found also in small frequencies and at much lower diversity in the Near East and parts of Africa, suggesting back-migration of people from northern Europe to the south.[3] Mitochondrial haplogroup U5a has also been associated with HIV infected individuals displaying accelerated progression to AIDS and death.[13] U5 has polymorphisms in the locations of 3197 9477 13617 16192 16270 U5a arose around 20000 years ago and have polymorphisms in 14793 16256 ( + U5 polymorphisms).[10] U5a1 arose around 16000 years ago and have polymorphisms in 15218 16399( + U5a polymorphisms). U5a1a arose around 15000 years ago and have polymorphisms in 1700 16192( + U5a1 polymorphisms). U5a1a1 arose around 12000 years ago and have polymorphisms in 5495 15924( + U5a1a polymorphisms). U5a1a1a has polymorphisms in 152 3816( + U5a1a1 polymorphisms). U5a1a2 has polymorphisms in 573.1C (deletion) 12346( + U5a1a polymorphisms). U5a1a2a has polymorphisms in 5319 6629 6719( + U5a1a2 polymorphisms). U5a1b arose around 11000 years ago and have polymorphisms in 9667 ( + U5a1 polymorphisms). U5a1b1 arose around 10000 years ago and have polymorphisms in 16291 ( + U5a1b polymorphisms). U5a1b1a has polymorphisms in 356.1C (deletion) 4553 ( + U5a1b1 polymorphisms). U5a1b1b has polymorphisms in 8119 ( + U5a1b1 polymorphisms). U5a1b1c has polymorphisms in 9055 ( + U5a1b1 polymorphisms). U5a1b1d has polymorphisms in 12358 16093 ( + U5a1b1 polymorphisms). U5a1b1e has polymorphisms in 12582 16192 16294 ( + U5a1b1 polymorphisms). U5a1b2 has polymorphisms in 9632 ( + U5a1b polymorphisms). U5a1b3 has polymorphisms in 16362 16428 ( + U5a1b polymorphisms). U5a1c arose around 13000 years ago and has polymorphisms in 16320 ( + U5a1 polymorphisms). U5a1c1 has polymorphisms in 195 13802 ( + U5a1c polymorphisms). U5a1c2 has polymorphisms in 961 965.1C (deletion)( + U5a1c polymorphisms). U5a1d arose around 19000 years ago and has polymorphisms in 3027 ( + U5a1 polymorphisms). U5a1d1 has polymorphisms in 5263 13002 (to adenosine)( + U5a1d polymorphisms). U5a1d2 has polymorphisms in 573.1C (deletion) 3552 (+ U5a1d polymorphisms). U5a1d2a has polymorphisms in 195 4823 5583 16145 16189 (+ U5a1d2 polymorphisms). U5a1e have polymorphisms in 3564 8610 ( + U5a1 polymorphisms). U5a1f have polymorphisms in 6023 ( + U5a1 polymorphisms). U5a2 arose around 14000 years ago and has polymorphisms in 16526( + U5a polymorphisms). U5a2a arose around 6000 years ago and has polymorphisms in 13827 13928C 16114 16294 ( + U5a2 polymorphisms). U5a2b arose around 8000 years ago and has polymorphisms in 9548 ( + U5a2 polymorphisms). U5a2c arose around 13000 years ago and has polymorphisms in 10619( + U5a2 polymorphisms). U5a2d and has polymorphisms in 7843 7978 8104 11107 16192! (backmutated in 16192 to the original Cambridge sequence) ( + U5a2 polymorphisms). U5a2e and has polymorphisms in 151 152 3768 15289 16189 16311 16362 ( + U5a2 polymorphisms). U5b arose around 24000 years ago and has polymorphisms in 150 7768 14182( + U5 polymorphisms). U5b1 arose around 18000 years ago and has polymorphisms in 5656( + U5b polymorphisms). U5b1b: has been found in Fulbe and Papel people in Guinea-Bissau and Yakuts people of northeastern Siberia.[14][15] It arose around 11000 years ago and have polymorphisms in 12618 16189 ( + U5b1 polymorphisms). U5b2 U5b3: The subclade is found primary on the island of Sardinia.[16] Haplogroup U6 Haplogroup U6 was named 'Ulla' by Bryan Sykes. It is common (around 10% of the people) [3] in North Africa (with a maximum of 29% in an Algerian Berber people[17]) and the Canary Islands (18%). It is also found in the Iberian peninsula, where it has the highest diversity (10 out of 19 sublineages are only found in this region and not in Africa),[17] Eastern Africa and occasionally in other locations. U6 is thought to have entered North Africa around 30,000 years ago from the Near-East. In spite of the highest diversity of Iberian U6, Maca-Meyer argues for an Iberian origin of this clade based on the highest diversity of subclade U6a in that region,[17] where it would have arrived from West Asia. She estimates the age of U6 between 25,000 and 66,000 years BP. However U6 has its highest frequencies in North Africa and seems to be a specific haplogroup of that region. U6 has three main subclades:[17] Subgroup U6a reflects the first African expansion from the Maghrib returning to the east in Paleolithic times. Derivative clade U6a1 signals a posterior movement from East Africa back to the Maghrib and the Near East. This migration coincides with the probable Afroasiatic linguistic expansion. U6b and U6c clades, restricted to West Africa, had more localized expansions. U6b probably reached the Iberian Peninsula during the Capsian diffusion in North Africa. Two autochthonous derivatives of these clades (U6b1 and U6c1) indicate the arrival of North African settlers to the Canarian Archipelago in prehistoric times, most probably due to the Saharan desiccation. The absence of these Canarian lineages nowadays in Africa suggests important demographic movements in the western area of this Continent. —Maca-Meyer 2003 U6a: it is the most widespread (from Canary Islands and Iberian Peninsula to Syria, Ethiopia and Kenya) and has highest diversity in Eastern Africa. Estimated age: 24-27,500 BP. It has one major subclade: U6a1: with similar distribution to U6a. Estimated age: 15-20,000 BP. I was also found in Brittany (France) at 4.5% frequency (1/22)[18] U6b: shows a more patched and western distribution. In the Iberian peninsula U6b is more frequent in the North (while U6a is in the South). It has also been found in low amounts in Morocco, Algeria, Senegal and Nigeria. Estimated age: 8,500-24,500 BP. It has one subclade: U6b1: found only in the Canary Islands and in the Iberian peninsula. Estimated age: c. 6000 BP. U6c: only found in Morocco and Canary Islands. Estimated age: 6,000-17,500 BP. U6a and U6b share a common basal mutation (16219) that is not present in U6c. Haplogroup U7 Many European populations lack Haplogroup U7 (named 'Ulaana' by Bryan Sykes), but its frequency climbs over 4% in the Near East and up to 5% in Pakistan, reaching nearly 10% level in Iranians. In India, haplogroup U7 frequency peaks at over 12% in Gujarat, the westernmost state of India, while for the whole of India its frequency stays around 2%. Expansion times and haplotype diversities for the Indian and Near and Middle Eastern U7 mtDNAs are strikingly similar. The possible homeland of this haplogroup spans Indian Gujarat and Iran because from there its frequency declines steeply both to the east and to the west. If the origin were in Iran rather than in India, then its equally high frequency as well as diversity in Gujarat favors a scenario whereby U7 has been introduced to the coastal western India either very early, or by multiple founders.[5] Haplogroup U8 U8a: The Basques have the most ancestral phylogeny in Europe for the mitochondrial haplogroup U8a, a rare subgroup of U8, placing the Basque origin of this lineage in the Upper Palaeolithic. The lack of U8a lineages in Africa suggests that their ancestors may have originated from West Asia.[2] U8b: This clade has been found in Italy and Jordan.[2] Haplogroup K Haplogroup K (named 'Katrine' by Bryan Sykes) makes up a sizeable fraction of European and West Asian mtDNA lineages. It is now known it is actually a subclade of haplogroup U8b'K,[2] and is believed to have first arisen in northeastern Italy. Haplogroup UK shows some evidence of being highly protective against AIDS progression.[13] Tree This phylogenetic tree of haplogroup U subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[1] and subsequent published research. mtDNA HG "U" p-tree U U1 U1a'c U1a U1a1 U1a2 U1a3 U1c U1b U5 U5a U5a1 U5a1a U5a1a1 U5a1b U5a1b1 U5a1b1a U5a2 U5a2a U5a2b U5a2c U5a2d U5b U5b1 U5b1b U5b1b1 U5ab1b1a U5ab1b1a1 U5b1b1b U5b1b2 U5b1c U5b1d U5b1e U5b2 U5b2a U5b2a1 U5b2a1a U5b2a2 U5b2a2a U5b2b U5b2c U5b3 U5b3a U6 U6a'b'd U6a U6a1 U6a1a U6a1b U6a2 U6a2a U6a3 U6a4 U6a5 U6a6 U6a7 U6a7a U6a7a1 U6a7b U6b U6b1 U6d U6d1 U6c U2'3'4'7'8 U2 U2a U2b U2b1 U2b2 U2c U2c1 U2d U2e U2e1 U2e1a U2e1a1 U2e2 U3 U3a U3a1 U3a2 U3b U3b1 U3b1a U3b2 U4'9 U4 U4a U4a1 U4a1a U4a1b U4a1c U4a2 U4a2a U4a2a1 U4a2b U4a2c U4a2c1 U4a3 U4b U4b1 U4b1a U4b1a1 U4b1a2 U4b1a3 U4b1a3a U4b1b U4b2 U4c U4c1 U4d U4d1 U4d2 U9 U9a U9b U7 U7a U8 U8a U8a1 U8a1a U8b'K U8b K See also Genealogical DNA test Genetic Genealogy Human mitochondrial genetics Population Genetics Evolutionary tree of Human mitochondrial DNA (mtDNA) haplogroups   Mitochondrial Eve (L)     L0 L1 L2 L3   L4 L5 L6   M N   CZ D E G Q   A S   R   I W X Y C Z B F R0   pre-JT P  U HV JT K H V J T References ^ a b van Oven M, Kayser M (February 2009). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation 30 (2): E386–94. doi:10.1002/humu.20921. PMID 18853457.  ^ a b c d González AM, García O, Larruga JM, Cabrera VM (2006). "The mitochondrial lineage U8a reveals a Paleolithic settlement in the Basque country". BMC Genomics 7: 124. doi:10.1186/1471-2164-7-124. PMC 1523212. PMID 16719915.  ^ a b c The Genographic Project at National Geographic ^ mtDNA Haplogroup U1a page at ^ a b Metspalu M, Kivisild T, Metspalu E, et al. (August 2004). "Most of the extant mtDNA boundaries in south and southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans". BMC Genetics 5: 26. doi:10.1186/1471-2156-5-26. PMC 516768. PMID 15339343.  ^ FTDNA mtDNA U2 Haplogroup project. ^ "DNA analysed from early European". BBC News. 2010-01-01. Retrieved 2010-05-04.  ^ Richards M, Macaulay V, Hickey E, et al. (November 2000). "Tracing European founder lineages in the Near Eastern mtDNA pool". American Journal of Human Genetics 67 (5): 1251–76. doi:10.1016/S0002-9297(07)62954-1. PMC 1288566. PMID 11032788.  ^ Quintana-Murci L, Chaix R, Wells RS, et al. (May 2004). "Where west meets east: the complex mtDNA landscape of the southwest and Central Asian corridor". American Journal of Human Genetics 74 (5): 827–45. doi:10.1086/383236. PMC 1181978. PMID 15077202.  ^ a b Malyarchuk BA, Grzybowski T, Derenko MV, Czarny J, Miścicka-Sliwka D (March 2006). "Mitochondrial DNA diversity in the Polish Roma". Annals of Human Genetics 70 (2): 195–206. doi:10.1111/j.1529-8817.2005.00222.x. PMID 16626330.  ^ Barbujani G, Bertorelle G (January 2001). "Genetics and the population history of Europe". Proceedings of the National Academy of Sciences of the United States of America 98 (1): 22–5. doi:10.1073/pnas.98.1.22. PMC 33353. PMID 11136246.  ^ Bramanti B, Thomas MG, Haak W, et al. (October 2009). "Genetic discontinuity between local hunter-gatherers and central Europe's first farmers". Science 326 (5949): 137–40. doi:10.1126/science.1176869. PMID 19729620.  ^ a b Hendrickson SL, Hutcheson HB, Ruiz-Pesini E, et al. (November 2008). "Mitochondrial DNA haplogroups influence AIDS progression". AIDS 22 (18): 2429–39. doi:10.1097/QAD.0b013e32831940bb. PMC 2699618. PMID 19005266.  ^ Rosa A, Ornelas C, Jobling MA, Brehm A, Villems R (2007). "Y-chromosomal diversity in the population of Guinea-Bissau: a multiethnic perspective". BMC Evolutionary Biology 7: 124. doi:10.1186/1471-2148-7-124. PMC 1976131. PMID 17662131.  ^ Achilli A, Rengo C, Battaglia V, et al. (May 2005). "Saami and Berbers--an unexpected mitochondrial DNA link". American Journal of Human Genetics 76 (5): 883–6. doi:10.1086/430073. PMC 1199377. PMID 15791543.  ^ Pala M, Achilli A, Olivieri A, et al. (June 2009). "Mitochondrial haplogroup U5b3: a distant echo of the epipaleolithic in Italy and the legacy of the early Sardinians". American Journal of Human Genetics 84 (6): 814–21. doi:10.1016/j.ajhg.2009.05.004. PMC 2694970. PMID 19500771.  ^ a b c d Maca-Meyer N, González AM, Pestano J, Flores C, Larruga JM, Cabrera VM (October 2003). "Mitochondrial DNA transit between West Asia and North Africa inferred from U6 phylogeography". BMC Genetics 4: 15. doi:10.1186/1471-2156-4-15. PMC 270091. PMID 14563219.  ^ External links General Ian Logan's Mitochondrial DNA Site Mannis van Oven's Phylotree Metspalu M, Kivisild T, Metspalu E, et al. (August 2004). "Most of the extant mtDNA boundaries in south and southwest Asia were likely shaped during the initial settlement of Eurasia by anatomically modern humans". BMC Genetics 5: 26. doi:10.1186/1471-2156-5-26. PMC 516768. PMID 15339343.  Haplogroup U The mtDNA Haplogroup U Project at Family Tree DNA Danish Demes Regional DNA Project: mtDNA Haplogroup U Spread of Haplogroup U, from National Geographic Haplogroup U1 The mtDNA Haplogroup U1 Project at Family Tree DNA Haplogroup U2 The mtDNA Haplogroup U2 Project at Family Tree DNA Haplogroup U4 The mtDNA Haplogroup U4 Project at Family Tree DNA A blog dedicated to the U4 Haplogroup Haplogroup U5 MtDNA Haplogroup U5 Webpage at Brian Hamman's Clan Ursula Website about U5 Haplogroup U6 The mtDNA Haplogroup U6 Project at Family Tree DNA The U6b Website Haplogroup U7 The U7 Haplogroup Mitochondrial DNA Project at Family Tree DNA Haplogroup U8 The U8 Haplogroup Mitochondrial DNA Project at Family Tree DNA