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(February 2009) edit Interleukin 18 binding protein Identifiers Symbols IL18BP; IL18BPa External IDs OMIM: 604113 MGI: 1333800 HomoloGene: 7781 GeneCards: IL18BP Gene Gene Ontology Molecular function • molecular_function • interleukin-18 binding • receptor antagonist activity Cellular component • cellular_component • extracellular region Biological process • biological_process • T-helper 1 type immune response Sources: Amigo / QuickGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 10068 16068 Ensembl ENSG00000137496 ENSMUSG00000070427 UniProt O95998 Q4FJR8 RefSeq (mRNA) NM_001039659 NM_010531 RefSeq (protein) NP_001034748 NP_034661 Location (UCSC) Chr 11: 71.39 - 71.39 Mb Chr 7: 101.89 - 101.89 Mb PubMed search [1] [2] Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene.[1][2] The protein encoded by this gene is an inhibitor of the proinflammatory cytokine IL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Three transcript variants encoding the same protein have been found for this gene.[2] References ^ Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M (Mar 1999). "Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response". Immunity 10 (1): 127–36. doi:10.1016/S1074-7613(00)80013-8. PMID 10023777.  ^ a b "Entrez Gene: IL18BP interleukin 18 binding protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10068.  Further reading Dinarello CA (2002). "Novel targets for interleukin 18 binding protein.". Ann. Rheum. Dis. 60 Suppl 3: iii18–24. PMID 11890646.  Loughney K, Martins TJ, Harris EA, et al. (1996). "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases.". J. Biol. Chem. 271 (2): 796–806. doi:10.1074/jbc.271.2.796. PMID 8557689.  Aizawa Y, Akita K, Taniai M, et al. (1999). "Cloning and expression of interleukin-18 binding protein.". FEBS Lett. 445 (2-3): 338–42. doi:10.1016/S0014-5793(99)00148-9. PMID 10094485.  Xiang Y, Moss B (1999). "Identification of human and mouse homologs of the MC51L-53L-54L family of secreted glycoproteins encoded by the Molluscum contagiosum poxvirus.". Virology 257 (2): 297–302. doi:10.1006/viro.1999.9676. PMID 10329540.  Kim SH, Eisenstein M, Reznikov L, et al. (2000). "Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18.". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1190–5. doi:10.1073/pnas.97.3.1190. PMID 10655506.  Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMID 10737800.  Michibata H, Yanaka N, Kanoh Y, et al. (2001). "Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization.". Biochim. Biophys. Acta 1517 (2): 278–87. PMID 11342109.  Paulukat J, Bosmann M, Nold M, et al. (2001). "Expression and release of IL-18 binding protein in response to IFN-gamma.". J. Immunol. 167 (12): 7038–43. PMID 11739524.  Fidock M, Miller M, Lanfear J (2002). "Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants.". Cell. Signal. 14 (1): 53–60. doi:10.1016/S0898-6568(01)00207-8. PMID 11747989.  Corbaz A, ten Hove T, Herren S, et al. (2002). "IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease.". J. Immunol. 168 (7): 3608–16. PMID 11907126.  Bufler P, Azam T, Gamboni-Robertson F, et al. (2002). "A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity.". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13723–8. doi:10.1073/pnas.212519099. PMID 12381835.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  Hurgin V, Novick D, Rubinstein M (2003). "The promoter of IL-18 binding protein: activation by an IFN-gamma -induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein beta.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16957–62. doi:10.1073/pnas.262663399. PMID 12482935.  Plitz T, Saint-Mézard P, Satho M, et al. (2003). "IL-18 binding protein protects against contact hypersensitivity.". J. Immunol. 171 (3): 1164–71. PMID 12874202.  Fantuzzi G, Banda NK, Guthridge C, et al. (2004). "Generation and characterization of mice transgenic for human IL-18-binding protein isoform a.". J. Leukoc. Biol. 74 (5): 889–96. doi:10.1189/jlb.0503230. PMID 12960225.  Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  Kawashima M, Novick D, Rubinstein M, Miossec P (2004). "Regulation of interleukin-18 binding protein production by blood and synovial cells from patients with rheumatoid arthritis.". Arthritis Rheum. 50 (6): 1800–5. doi:10.1002/art.20320. PMID 15188356.  Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.  This article on a gene on chromosome 11 is a stub. You can help Wikipedia by expanding it.v · d · e